[Cardiovascular adverse effects due to phenylephrine eye drops in ophtalmic surgery].

[Cardiovascular adverse effects due to phenylephrine eye drops in ophtalmic surgery].

Annales francaises d'anesthesie et de reanimation (2013-02-05)

S Kauffmann, F Commun, P Schoeffler, G Souteyrand, F Chiambaretta, P Dewachter

ABSTRACT

Adverse systemic reactions such as cardiovascular effects may occur following topical ocular application of phenylephrine. We report the case of a 49-year-old woman who, following topical application of phenylephrine eyedrops, experienced hypertension with electrocardiographic modifications and a rise in cardiac troponin Ic.

MATERIALS

Product Number

Brand

Product Description

PHR1017

Supelco

Phenylephrine Hydrochloride, Pharmaceutical Secondary Standard; Certified Reference Material

P6126

Sigma-Aldrich

(R)-(−)-Phenylephrine hydrochloride, powder

P8155

Sigma-Aldrich

(R)-(−)-Phenylephrine hydrochloride, analytical standard

P-078

Supelco

R-(-)-Phenylephrine hydrochloride solution, 1.0 mg/mL in methanol (as free base), ampule of 1 mL, certified reference material, Cerilliant^®

Y0000683

Phenylephrine hydrochloride for peak identification, European Pharmacopoeia (EP) Reference Standard