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[General situation of the study on the toxicity of Cinnabaris].

Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica (2005-02-24)
Ai-hua Liang, Min-feng Shang
ABSTRACT

Traditional Chinese medicine (TCM) experienced a gradual course in recognition of the toxicity of Cinnabaris from "nontoxic" to "toxic". The ancient doctors of TCM understood both the toxic property and the regularity of increasing toxicity of Cinnabaris. In long-term clinical practice they developed the methods of detoxification guiding the safe use of Cinnabaris. The toxicity of Cinnabaris is produced by mercury existed in it. Improper administration leading to an acute absorption or chronic accumulation was the main cause of clinical adverse effects. Kidney was the main poisoning target organ. On the other hand, improperly combinative application of Cinnabaris with other drugs of TCM or western medicine could increase the toxicity. Therefore, the crucial approach to avoid the poisoning is to use Cinnabaris properly.

MATERIALS
Product Number
Brand
Product Description

Supelco
Mercury(II) sulfate, ACS reagent, for preparation of solution for COD determination according to DIN 38409, part 41, ≥99%
Sigma-Aldrich
Mercury(II) sulfate, puriss., ≥98%