SAB4300499

Anti-MAPK14 (Ab-182) antibody produced in rabbit

affinity isolated antibody

• Synonym(s): Anti-CSBP1 antibody produced in rabbit, Anti-CSBP2 antibody produced in rabbit, Anti-CSPB1 antibody produced in rabbit, Anti-EXIP antibody produced in rabbit, Anti-mitogen-activated protein kinase 14 antibody produced in rabbit
• UNSPSC Code: 12352203
• NACRES: NA.41

Properties

• biological source: rabbit
• conjugate: unconjugated
• antibody form: affinity isolated antibody
• antibody product type: primary antibodies
• clone: polyclonal
• form: buffered aqueous solution
• mol wt: ~43 kDa
• species reactivity: rat, mouse, human
• concentration: 1 mg/mL
• technique(s): western blot: 1:500-1:1000
• isotype: IgG
• immunogen sequence: (T-G-Y-V-A)
• NCBI accession no.: NP_001306.1
• UniProt accession no.: Q16539
• shipped in: wet ice
• storage temp.: −20°C
• target post-translational modification: unmodified
• Gene Information: human ... MAPK14(1432)

Description

Immunogen

Peptide sequence around aa. 180-184 (T-G-Y-V-A), according to the protein MAPK14.

Features and Benefits

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Target description

Responds to activation by environmental stress, pro-inflammatory cytokines and lipopolysaccharide (LPS) by phosphorylating a number of transcription factors, such as ELK1 and ATF2 and several downstream kinases, such as MAPKAPK2 and MAPKAPK5. Plays a critical role in the production of some cytokines, for example IL-6. May play a role in stabilization of EPO mRNA during hypoxic stress. Isoform Mxi2 activation is stimulated by mitogens and oxidative stress and only poorly phosphorylates ELK1 and ATF2. Isoform Exip may play a role in the early onset of apoptosis.

Physical form

Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol

Safety Information

• Storage Class Code: 10 - Combustible liquids
• WGK: WGK 1
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable