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P5234
Purvalanol B
≥97% (HPLC), solid
Synonym(s):
(2R)-2-[[6-[(3-Chloro-4-carboxyphenyl)amino]-9-(1-methylethyl)-9H-purin-2-yl]amino]-3-methyl-1-butanol, NG 95
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₪496.00
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About This Item
Empirical Formula (Hill Notation):
C20H25ClN6O3
CAS Number:
Molecular Weight:
432.90
MDL number:
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
₪496.00
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Quality Level
Assay
≥97% (HPLC)
form
solid
solubility
DMSO: soluble 37 mg/mL
H2O: insoluble
shipped in
dry ice
storage temp.
−20°C
SMILES string
CC(C)[C@H](CO)Nc1nc(Nc2ccc(C(O)=O)c(Cl)c2)c3ncn(C(C)C)c3n1
InChI
1S/C20H25ClN6O3/c1-10(2)15(8-28)24-20-25-17(16-18(26-20)27(9-22-16)11(3)4)23-12-5-6-13(19(29)30)14(21)7-12/h5-7,9-11,15,28H,8H2,1-4H3,(H,29,30)(H2,23,24,25,26)/t15-/m0/s1
InChI key
ZKDXRFMOHZVXSG-HNNXBMFYSA-N
Biochem/physiol Actions
Purvalanol B is a cyclin-dependent; 2,6,9-substituted kinase inhibitor.
Packaging
Bottomless glass bottle. Contents are inside inserted fused cone.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
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Voin Petrovic et al.
Nutrients, 10(4) (2018-04-06)
The use of garlic and garlic-based extracts has been linked to decreased incidence of cancer in epidemiological studies. Here we examine the molecular and cellular activities of a simple homemade ethanol-based garlic extract (GE). We show that GE inhibits growth
Alison M Kurimchak et al.
Science signaling, 13(619) (2020-02-20)
High-grade serous ovarian carcinoma (HGSOC) is the most lethal gynecological cancer with few effective, targeted therapies. HGSOC tumors exhibit genomic instability with frequent alterations in the protein kinome; however, only a small fraction of the kinome has been therapeutically targeted
Voin Petrovic et al.
Analytical biochemistry, 523, 10-16 (2017-02-09)
The Multiplexed Inhibitor Bead (MIB) assay is a previously published quantitative proteomic MS-based approach to study cellular kinomes. A rather extensive procedure, need for multiple custom-made kinase inhibitors and an inability to re-use the MIB-columns, has limited its applicability. Here
Matthew B Lipner et al.
JCI insight, 5(8) (2020-03-28)
Over 55,000 people in the United States are diagnosed with pancreatic ductal adenocarcinoma (PDAC) yearly, and fewer than 20% of these patients survive a year beyond diagnosis. Chemotherapies are considered or used in nearly every PDAC case, but there is
Peng Luo et al.
Cell death & disease, 10(7), 496-496 (2019-06-27)
Traumatic brain injury (TBI) has become a major health concern worldwide, and the poor outcome of TBI increases the need for therapeutic improvement. Secondary injuries following TBI, including excitotoxicity, lead to synaptic dysfunction and provide potential targets for intervention. Postsynaptic
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How does the storage temperature relate to shipping conditions?
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The storage conditions that a Sigma-Aldrich catalog and label recommend for products are deliberately conservative. For many products, long-term storage at low temperatures will increase the time during which they are expected to remain in specification and therefore are labeled accordingly. Where short-term storage, shipping time frame, or exposure to conditions other than those recommended for long-term storage will not affect product quality, Sigma-Aldrich will ship at ambient temperature. The products sensitive to short-term exposure to conditions other than their recommended long-term storage are shipped on wet or dry ice. Ambient temperature shipping helps to control shipping costs for our customers. At any time, our customers can request wet- or dry-ice shipment, but the special handling is at customer expense if our product history indicates that the product is stable for regular shipment.
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At what concentration is Product P5234, Purvalanol B, soluble in DMSO?
1 answer-
We have not necessarily tested a maximum value for solubility of Product P5234, Purvalanol B, in DMSO. However, one publication indicates preparation of a 100 mM stock solution in DMSO. Holton, S., et al., Structures of P. falciparum PfPK5 Test the CDK Regulation Paradigm and Suggest Mechanisms of Small Molecule Inhibition. Structure, 11(11), 1329-1337 (2003).
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