MAK257
Tyrosinase Inhibitor Screening Kit (Colorimetric)
sufficient for 100 colorimetric tests
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About This Item
UNSPSC Code:
12161503
NACRES:
NA.25
Recommended Products
application(s)
cosmetics
food and beverages
detection method
colorimetric
relevant disease(s)
dermatological diseases
storage temp.
−20°C
General description
Tyrosinase or polyphenol oxidase (EC 1.14.18.1), is an oxidoreductase that participates in the biosynthesis of melanin, a ubiquitous biological pigment found in hair, eyes, skin, etc. Inhibition of tyrosinase has been a long-time target in the skin health research, cosmetics and agricultural industries because of its role in browning reactions in skin pigmentation and during fruit harvesting and handling. Skin whitening and bleaching products utilize natural or synthetic tyrosinase inhibitors in order to lighten the skin color. Polyphenols, benzaldehyde derivatives, long-chain lipids, steroids, and natural compounds have been used as tyrosinase inhibitors.
Deficiency in tyrosinase causes albino, a condition in which the melanocytes are not able to produce melanin. This increases the risk of skin cancer.
Deficiency in tyrosinase causes albino, a condition in which the melanocytes are not able to produce melanin. This increases the risk of skin cancer.
Features and Benefits
Compatible with high-throughput handling systems.
Suitability
Suitable for screening/studying/characterizing tyrosinase inhibitors.
Principle
Tyrosinase catalyzes the oxidation of tyrosine, producing a chromophore that can be detected at 510 nm. In the presence of kojic acid, a reversible inhibitor of tyrosinase, the rate of oxidation of the substrate is decreased. The kit provides a rapid, simple, sensitive, and reliable test suitable for high-throughput screening of tyrosinase inhibitors. The assay is also adaptable to a 384 well format.
Signal Word
Danger
Hazard Statements
Precautionary Statements
Hazard Classifications
Eye Dam. 1 - Resp. Sens. 1
Storage Class Code
10 - Combustible liquids
Flash Point(F)
188.6 °F
Flash Point(C)
87 °C
Certificates of Analysis (COA)
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