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Merck

SIRT3

sirtuin 3

Synonyms:
SIR2L3
Species:
UniProtKB ID:
Gene ID:
  • Human(23410) Summary: This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family. Two alternatively spliced transcript variants that encode different proteins have been described for this gene. [provided by RefSeq, Jul 2008]
  • Mouse(64384) sirtuin 3
  • Rat(293615) sirtuin 3
  • cow(614027) sirtuin 3
  • Domestic Rabbit(100354500) sirtuin 3
  • sheep(101105454) sirtuin 3
  • domestic guinea pig(100714713) sirtuin 3
  • naked mole-rat(101697494) sirtuin 3
  • Zebrafish(558775) sirtuin (silent mating type information regulation 2 homolog) 3 (S. cerevisiae)
  • chicken(422988) sirtuin (silent mating type information regulation 2 homolog) 3 (S. cerevisiae)
  • domestic cat(101087609) sirtuin 3
  • dog(475933) sirtuin 3

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  • Custom Gene Products

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ELISA

Product Number
Description
Species
Human Sirtuin 3 ELISA, for serum, plasma and cell culture supernatants,
Species
human

Antibodies

Product Number
Description
Species Reactivity
Application
Anti-SIRT3 antibody produced in rabbit, IgG fraction of antiserum,
Species Reactivity
dog, horse, human, mouse, rat
Application
western blot
Anti-SIRT3 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human
Application
immunohistochemistry
western blot
Anti-Sirt3 antibody produced in rabbit, affinity isolated antibody, buffered aqueous solution,
Species Reactivity
human
Application
immunofluorescence
western blot
Anti-SIRT3 antibody produced in rabbit, ,
Species Reactivity
human, mouse, rat
Application
immunohistochemistry
western blot
ANTI-MOUSE SIRT3 (C-TERM) antibody produced in rabbit, IgG fraction of antiserum, buffered aqueous solution,
Species Reactivity
hamster, mouse
Application
immunohistochemistry
western blot

Proteins

Product Number
Description
Species
SIRT3, active, GST tagged human, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution,
Species
human
Sirtuin 3 human, recombinant, expressed in E. coli, ≥70% (SDS-PAGE),
Species
human

esiRNA

Product Number
Description
Species
MISSION® esiRNA, targeting human SIRT3,
Species
human