JAK1
Janus kinase 1
Synonyms:
JAK1A, JAK1B, JTK3
Species:
Human JAK1 (3716), Mouse Jak1 (16451), Rat Jak1 (84598), naked mole-rat Jak1 (101710283), domestic guinea pig Jak1 (100726895), Domestic Rabbit JAK1 (100352594), sheep JAK1 (101110716), domestic cat JAK1 (101084377), Horse JAK1 (100054008), cow JAK1 (537201) ...More
UniProtKB ID:
Gene ID:
- Human(3716) Summary: Janus kinase 1 (JAK1), is a member of a new class of protein-tyrosine kinases (PTK) characterized by the presence of a second phosphotransferase-related domain immediately N-terminal to the PTK domain. The second phosphotransferase domain bears all the hallmarks of a protein kinase, although its structure differs significantly from that of the PTK and threonine/serine kinase family members. JAK1 is a large, widely expressed membrane-associated phosphoprotein. JAK1 is involved in the interferon-alpha/beta and -gamma signal transduction pathways. The reciprocal interdependence between JAK1 and TYK2 activities in the interferon-alpha pathway, and between JAK1 and JAK2 in the interferon-gamma pathway, may reflect a requirement for these kinases in the correct assembly of interferon receptor complexes. These kinases couple cytokine ligand binding to tyrosine phosphorylation of various known signaling proteins and of a unique family of transcription factors termed the signal transducers and activators of transcription, or STATs. [provided by RefSeq, Jul 2008]
- Mouse(16451) Janus kinase 1
- Rat(84598) Janus kinase 1
- naked mole-rat(101710283) Janus kinase 1
- domestic guinea pig(100726895) Janus kinase 1
- Domestic Rabbit(100352594) Janus kinase 1
- sheep(101110716) Janus kinase 1
- domestic cat(101084377) Janus kinase 1
- Horse(100054008) Janus kinase 1
- cow(537201) Janus kinase 1
- dog(442952) Janus kinase 1
- Zebrafish(30280) Janus kinase 1
- chicken(395681) Janus kinase 1
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ELISA
Product Number
Description
Species
Antibodies
Product Number
Description
Species Reactivity
Application
Anti-JAK1 antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human, mouse, rat
Application
ELISA
immunohistochemistry
western blot
immunohistochemistry
western blot
Anti-Phospho-Jak1-Y1022/1023 antibody produced in rabbit, ,
Species Reactivity
human, mouse
Application
immunofluorescence
western blot
western blot
Anti-JAK1 Antibody, clone 73, clone 73, from mouse,
Species Reactivity
xenopus, canine, chicken, human, mouse, rat
Application
immunofluorescence
immunoprecipitation (IP)
western blot
immunoprecipitation (IP)
western blot
Anti-phospho-JAK1 (pTyr1022) antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human, mouse, rat
Application
ELISA
immunohistochemistry
western blot
immunohistochemistry
western blot
Anti-JAK1 Antibody, clone 7Q1B2, Rabbit Monoclonal, ,
Species Reactivity
human, rat
Application
immunohistochemistry
western blot
western blot
Proteins
Product Number
Description
Species
Jak1 active human, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE),
Species
human
JAK1 Protein, active, 10 µg, Active, N-terminal GST-tagged, recombinant, human JAK1, amino acids 866-end, expressed by baculovirus in Sf21 insect cells. Activated in vitro by auto-phosphorylation. For use in Kinase Assays.,
Species
human