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Merck

ESR1

estrogen receptor 1

Synonyms:
ER, ESR, ESRA, ESTRR, Era, NR3A1
Species:
Human ESR1 (2099), Mouse Esr1 (13982), Rat Esr1 (24890), domestic cat ESR1 (552888), dog ESR1 (403640), chicken ESR1 (396099), Thale Cress ESR1 (837856), Horse ESR1 (791249), Zebrafish esr1 (259252), cow ESR1 (407238) ...More
UniProtKB ID:
P03372, Q13511, Q14276, Q5T5H7, Q6MZQ9, Q9NU51, Q9UDZ7, Q9UIS7
Gene ID:
  • Human(2099) Summary: This gene encodes an estrogen receptor, a ligand-activated transcription factor composed of several domains important for hormone binding, DNA binding, and activation of transcription. The protein localizes to the nucleus where it may form a homodimer or a heterodimer with estrogen receptor 2. Estrogen and its receptors are essential for sexual development and reproductive function, but also play a role in other tissues such as bone. Estrogen receptors are also involved in pathological processes including breast cancer, endometrial cancer, and osteoporosis. Alternative splicing results in several transcript variants, which differ in their 5' UTRs and use different promoters. [provided by RefSeq, Jul 2008]
  • Mouse(13982) estrogen receptor 1 (alpha)
  • Rat(24890) estrogen receptor 1
  • domestic cat(552888) estrogen receptor 1
  • dog(403640) estrogen receptor 1
  • chicken(396099) estrogen receptor 1
  • Thale Cress(837856) ethylene-responsive transcription factor ESR1
  • Horse(791249) estrogen receptor 1
  • Zebrafish(259252) estrogen receptor 1
  • cow(407238) estrogen receptor 1
  • Goat(100860768) estrogen receptor 1
  • sheep(443228) estrogen receptor 1
  • domestic guinea pig(100713276) estrogen receptor 1

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Small Molecule - Activator

Product Number
Description
Species
131083
4-Phenylazophenol, 98%,
Species
human
N0632
β-Nicotinamide adenine dinucleotide sodium salt, ,
Species
human
262013
trans-4-Stilbenemethanol, ,
Species
human, rat
S4808
cis-Stilbene, 96%,
Species
human, rat
N8285
β-Nicotinamide adenine dinucleotide, pkg of 10 mg (per vial),
Species
human

Small Molecule - Agonist

Product Number
Description
Species
H6036
1,3,5-Tris(4-hydroxyphenyl)-4-propyl-1H-pyrazole, powder, ≥98% (HPLC),
Species
human
855871
Mestranol, 99%,
Species
human
E8004
β-Estradiol 17-cypionate, ,
Species
human
M0600000
Mestranol, European Pharmacopoeia (EP) Reference Standard,
Species
human
1394008
Mestranol, United States Pharmacopeia (USP) Reference Standard,
Species
human

Small Molecule - Allosteric Modulator

Product Number
Description
Species
T0015000
Tamoxifen citrate for performance test, European Pharmacopoeia (EP) Reference Standard,
Species
human
1643306
Tamoxifen citrate, United States Pharmacopeia (USP) Reference Standard,
Species
human
85256
Tamoxifen, analytical standard,
Species
human
T0014000
Tamoxifen citrate, European Pharmacopoeia (EP) Reference Standard,
Species
human
06734
Tamoxifen, certified reference material, TraceCERT®, Manufactured by: Sigma-Aldrich Production GmbH, Switzerland,
Species
human

Small Molecule - Antagonist

Product Number
Description
Species
308501
Benzyl butyl phthalate, 98%,
Species
mouse
524980
Dibutyl phthalate, 99%,
Species
mouse
290823
4-tert-Octylphenol, 97%,
Species
mouse
442858
4-tert-Octylphenol, analytical standard,
Species
mouse
C33301
2-Chloro-4,6-diamino-1,3,5-triazine, 95%,
Species
mouse

Antibodies

Product Number
Description
Species Reactivity
Application
SAB4301359
Anti-phospho-Estrogen Receptor-α (pSer102) antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human, mouse, rat
Application
immunohistochemistry
western blot
07-662
Anti-Estrogen-related Receptor α Antibody, Upstate®, from rabbit,
Species Reactivity
hamster, human, mouse, rat
Application
electrophoretic mobility shift assay
immunohistochemistry
immunoprecipitation (IP)
western blot
MAB1233
Anti-Estradiol Antibody, clone 6E1, ascites fluid, clone 6E1, Chemicon®,
Species Reactivity
human
Application
ELISA
SAB5600097
Anti-ER alpha antibody, Rabbit Monoclonal, recombinant, expressed in HEK 293 cells, clone RM292, purified immunoglobulin,
Species Reactivity
human
Application
immunohistochemistry
western blot
SAB5300308
Monoclonal Anti-ESR1 antibody produced in mouse, clone 6B6, ascites fluid,
Species Reactivity
human
Application
ELISA
immunofluorescence
immunohistochemistry
western blot

Small Molecule - Inhibitor

Product Number
Description
Species
D79403
Bicyclohexyl, 99%,
Species
human
W312908
Biphenyl, ≥99%,
Species
human
B34656
Biphenyl, ReagentPlus®, 99.5%,
Species
human
374784
4′-Hydroxy-4-biphenylcarbonitrile, 97%,
Species
human
168734
4,4′-Dihydroxybiphenyl, 97%,
Species
human

Small Molecule - Ligand

Product Number
Description
Species
46665
Progesterone, VETRANAL®, analytical standard,
Species
human
H4637
4-Hydroxyestradiol, ,
Species
rat, human
T5648
Tamoxifen, ≥99%,
Species
human, rat
T1500
Testosterone, ≥98%,
Species
mouse, human, rat
P0130
Progesterone, ≥99%,
Species
mouse, human, rat

Small Molecule - Mixed Agonist/Antagonist

Product Number
Description
Species
E8750
α-Estradiol, powder, ≥98% (TLC),
Species
human, rat
M1629
Medroxyprogesterone 17-acetate, ≥97% (HPLC),
Species
human, rat
E1024
Estradiol, meets USP testing specifications,
Species
human, mouse, rat
E1132
β-Estradiol, analytical standard,
Species
human, mouse, rat
E2758
β-Estradiol, BioReagent, powder, suitable for cell culture,
Species
human, mouse, rat

Proteins

Product Number
Description
Species
E1528
Estrogen Receptor-α human, ≥80% (SDS-PAGE), recombinant, expressed in baculovirus infected insect cells, buffered aqueous glycerol solution,
Species
human

esiRNA

Product Number
Description
Species
EHU141651
MISSION® esiRNA, targeting human ESR1,
Species
human