CAPN6
calpain 6
Synonyms:
CANPX, CAPNX, CalpM, DJ914P14.1
Species:
Human CAPN6 (827), Mouse Capn6 (12338), Rat Capn6 (83685), dog CAPN6 (492068), chicken CAPN6 (422341), naked mole-rat Capn6 (101712448), domestic guinea pig Capn6 (100720507), sheep CAPN6 (101110122), Domestic Rabbit CAPN6 (100348781), domestic cat CAPN6 (101095474) ...More
UniProtKB ID:
Gene ID:
- Human(827) Summary: Calpains are ubiquitous, well-conserved family of calcium-dependent, cysteine proteases. The calpain proteins are heterodimers consisting of an invariant small subunit and variable large subunits. The large subunit possesses a cysteine protease domain, and both subunits possess calcium-binding domains. Calpains have been implicated in neurodegenerative processes, as their activation can be triggered by calcium influx and oxidative stress. The protein encoded by this gene is highly expressed in the placenta. Its C-terminal region lacks any homology to the calmodulin-like domain of other calpains. The protein lacks critical active site residues and thus is suggested to be proteolytically inactive. The protein may play a role in tumor formation by inhibiting apoptosis and promoting angiogenesis. [provided by RefSeq, Nov 2009]
- Mouse(12338) calpain 6
- Rat(83685) calpain 6
- dog(492068) calpain 6
- chicken(422341) calpain 6
- naked mole-rat(101712448) calpain 6
- domestic guinea pig(100720507) calpain 6
- sheep(101110122) calpain 6
- Domestic Rabbit(100348781) calpain 6
- domestic cat(101095474) calpain 6
- Horse(100054264) calpain 6
- cow(539360) calpain 6
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Antibodies
Product Number
Description
Species Reactivity
Application
Anti-CAPN6 antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
Application
immunofluorescence
immunohistochemistry
western blot
immunohistochemistry
western blot