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  • Ru(II)/diphenylphosphine/pyridine-6-thiolate complexes induce S-180 cell apoptosis through intrinsic mitochondrial pathway involving inhibition of Bcl-2 and p53/Bax activation.

Ru(II)/diphenylphosphine/pyridine-6-thiolate complexes induce S-180 cell apoptosis through intrinsic mitochondrial pathway involving inhibition of Bcl-2 and p53/Bax activation.

Molecular and cellular biochemistry (2017-08-11)
Wanessa Carvalho Pires, Benedicto Augusto Vieira Lima, Flávia de Castro Pereira, Aliny Pereira Lima, Francyelli Mello-Andrade, Hugo Delleon Silva, Monize Martins da Silva, Legna Colina-Vegas, Javier Ellena, Alzir A Batista, Elisângela de Paul Silveira-Lacerda
PMID28795366
ABSTRACT

The aim of this work was the synthesis, characterization, and cytotoxicity evaluation of three new Ru(II) complexes with a general formula [Ru(Spy)(bipy)(P-P)]PF