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  • Potent small-molecule suppression of oxacillin resistance in methicillin-resistant Staphylococcus aureus.

Potent small-molecule suppression of oxacillin resistance in methicillin-resistant Staphylococcus aureus.

Angewandte Chemie (International ed. in English) (2012-10-11)
Tyler L Harris, Roberta J Worthington, Christian Melander
ABSTRACT

Shields down! Adjuvant molecules that have the ability to restore the susceptibility of multi-drug-resistant bacteria, such as MRSA, to clinically available antibiotics are a promising alternative to the development of novel antimicrobials. Pictured is a potent small molecule (1) that, at sub-minimum inhibitory concentration (sub-MIC) levels, lowers the MIC of oxacillin (2) against a number of MRSA strains by up to 512-fold.

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Supelco
Oxacillin sodium salt monohydrate, VETRANAL®, analytical standard
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Sigma-Aldrich
Oxacillin sodium salt, 815-950 μg/mg (Oxacillin)
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