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  • Rapid photo-crosslinking of fumaric acid monoethyl ester-functionalized poly(trimethylene carbonate) oligomers for drug delivery applications.

Rapid photo-crosslinking of fumaric acid monoethyl ester-functionalized poly(trimethylene carbonate) oligomers for drug delivery applications.

Journal of controlled release : official journal of the Controlled Release Society (2010-07-21)
Janine Jansen, Mark J Boerakker, Jean Heuts, Jan Feijen, Dirk W Grijpma
ABSTRACT

Photo-crosslinkable, fumaric acid monoethyl ester-functionalized poly(trimethylene carbonate) oligomers were synthesized and copolymerized with N-vinyl pyrrolidone (NVP) and vinyl acetate (VAc) to form biodegradable polymer networks. The copolymerization reactions were much faster than homopolymerization of the fumarate end-groups of the macromers. The hydrophilicity of the networks could by varied by mixing NVP and VAc at different ratios. The prepared network extracts were compatible with NIH 3T3 fibroblasts. Release of vitamin B12, used as a model drug, could be tuned by varying network hydrophilicity and macromer molecular weight. A more hydrophilic and less densely crosslinked network resulted in faster release.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
mono-Ethyl fumarate, 95%
Pricing and availability is not currently available.
Sigma-Aldrich
1-Vinyl-2-pyrrolidinone, contains sodium hydroxide as inhibitor, ≥99%
Pricing and availability is not currently available.
Sigma-Aldrich
Vinyl acetate, contains 3-20 ppm hydroquinone as inhibitor, ≥99%
Pricing and availability is not currently available.
Vinyl acetate, European Pharmacopoeia (EP) Reference Standard
Pricing and availability is not currently available.
Supelco
Vinyl acetate, analytical standard
Pricing and availability is not currently available.