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  • Lower nitric oxide susceptibility of trivalent antimony-resistant amastigotes of Leishmania infantum.

Lower nitric oxide susceptibility of trivalent antimony-resistant amastigotes of Leishmania infantum.

Antimicrobial agents and chemotherapy (2005-09-29)
P Holzmuller, D Sereno, J-L Lemesre
ABSTRACT

We previously documented the induction of Leishmania amastigote apoptosis by trivalent antimony (SbIII) and nitric oxide (NO). We demonstrate here that SbIII-resistant amastigotes were resistant to NO toxicity when delivered extracellularly by NO donors or intracellularly via macrophage activation. Shared biochemical targets for SbIII and NO resistance in Leishmania are discussed.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
Potassium antimonyl tartrate trihydrate, purum p.a., 99.0-103% (RT)
Sigma-Aldrich
Potassium antimonyl tartrate trihydrate, puriss., meets analytical specification of USP, 99.0-103.0%, powder
Sigma-Aldrich
Potassium antimonyl tartrate trihydrate, ACS reagent, ≥99%