- Selective inhibitory effects of hybrid liposomes on the growth of HIV type 1-infected cells in vitro.
Selective inhibitory effects of hybrid liposomes on the growth of HIV type 1-infected cells in vitro.
Bioorganic & medicinal chemistry letters (2008-08-02)
Ryuichi Ueoka, Yuji Komizu, Yoko Matsumoto, Yu Zhong, Ritsuko Tanaka, Naoki Yamamoto
PMID18672367
ABSTRACT
A good correlation between fifty-percent inhibitory concentration (IC(50)) of hybrid liposomes (HL) composed of dimyristoylphosphatidylcholine and polyoxyethylene(n) dodecyl ether on the growth of MOLT-4/IIIB cells (MOLT-4 cells chronically infected with human immunodeficiency virus (HIV)) and the membrane fluidity of HL was obtained. Furthermore, the huge enhancement of virus production was observed in the latently HIV-infected (J(22)-HL-60) cells after the treatment with HL.
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