53439

Glutaconic acid

analytical standard

• Synonym(s): 2-Pentenedioic acid
• Linear Formula: HOOCCH₂CH=CHCOOH
• CAS Number: 1724-02-3
• Molecular Weight: 130.10
• Beilstein: 1759560
• MDL number: MFCD00002784
• UNSPSC Code: 41116107

Properties

• grade: analytical standard
• Assay: ≥96.5% (HPLC)
• shelf life: limited shelf life, expiry date on the label
• application(s): clinical testing
• format: neat
• SMILES string: OC(=O)C\C=C\C(O)=O
• InChI: 1S/C5H6O4/c6-4(7)2-1-3-5(8)9/h1-2H,3H2,(H,6,7)(H,8,9)/b2-1+
• InChI key: XVOUMQNXTGKGMA-OWOJBTEDSA-N

Description

General description

Glutaconic acid is a short chain carboxylic acid which accumulates in the physiological body fluids in patients with deficiency of glutaryl-CoA dehydrogenase leading to glutaric aciduria type 1 disorder (GA1). It finds applications as a diagnostic biomarker since it is found in increased concentrations in the urine of patients with GA1. It can be detected by gas chromatography-mass spectrometry in biological fluids including urine, cerebrospinal fluid, and serum.

Application

Glutaconic acid may be used as a standard to investigate its role in the induction of the mitochondrial permeability transition (MPT) in the isolated rat liver mitochondria in vitro.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable