14-645-M

IRR Protein, active, 10 µg

• UNSPSC Code: 12352202
• eCl@ss: 32160405
• NACRES: NA.32

Properties

• Quality Level: 300
• description: protein target IRR
• purified by: (Ni²⁺/NTA-agarose)
• technique(s): activity assay: suitable
• UniProt accession no.: P14616
• Gene Information: human ... INSRR(3645)

Description

General description

FUNCTION: SwissProt: P14616 # This receptor probably binds an insulin related protein and has a tyrosine-protein kinase activity. It phosphorylates the insulin receptor substrates IRS-1 and IRS-2.
SIZE: 1297 amino acids; 143720 Da
SUBUNIT: Probable tetramer of 2 alpha and 2 beta chains linked by disulfide bonds. The alpha chains contribute to the formation of the ligand-binding domain, while the beta chains carry the kinase domain.
SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
SIMILARITY: SwissProt: P14616 ## Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily. & Contains 4 fibronectin type-III domains. & Contains 1 protein kinase domain.

Packaging

Also available in 10 μg size (cat#14-645) and in bulk (cat#14-645-K).

Quality

Routinely evaluated by phosphorylation of MBP (13-104).

routinely evaluated by phosphorylation of MBP (13-104).

Physical properties

37.9kDa

Storage and Stability

6 months at -70°C

Analysis Note

For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.