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F-013

Supelco

Fentanyl solution

1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®

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About This Item

Empirical Formula (Hill Notation):
C22H28N2O
CAS Number:
437-38-7
Molecular Weight:
336.47
MDL number:
MFCD00661055
UNSPSC Code:
41116107
PubChem Substance ID:
329799631
NACRES:
NA.24

grade

certified reference material

form

liquid

feature

Snap-N-Spike®/Snap-N-Shoot®

packaging

ampule of 1 mL

manufacturer/tradename

Cerilliant®

drug control

Narcotic Licence Schedule A (Switzerland); estupefaciente (Spain); Decreto Lei 15/93: Tabela IA (Portugal)

concentration

1.0 mg/mL in methanol

technique(s)

gas chromatography (GC): suitable
liquid chromatography (LC): suitable

application(s)

forensics and toxicology

format

single component solution

storage temp.

−20°C

SMILES string

CCC(=O)N(C1CCN(CC1)CCc2ccccc2)c3ccccc3

InChI

1S/C22H28N2O/c1-2-22(25)24(20-11-7-4-8-12-20)21-14-17-23(18-15-21)16-13-19-9-5-3-6-10-19/h3-12,21H,2,13-18H2,1H3

InChI key

PJMPHNIQZUBGLI-UHFFFAOYSA-N

Gene Information

human ... OPRM1(4988)

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General description

This certified solution standard is suitable for a variety of LC/MS or GC/MS testing applications from forensic analysis, clinical toxicology, and pain prescription monitoring to urine drug testing and pharmaceutical research.

Fentanyl belongs to the class of synthetic opioids and shows potent μ-opioid receptor agonistic behavior. It is known for its anesthetic and analgesic properties and is known to be 100 times more potent than heroin. Sold under various trade names including Sublimaze, Duragesic®, Actiq®, and Fentora®, fentanyl is more potent than morphine in analgesic activity.

Application

The certified reference solution (CRM) in solution can also be used as follows:
  • Multi-residue analysis of fentanyl and its derivatives in hair samples using a liquid chromatography-tandem mass spectrometry (LC-MS/MS) based procedure
  • Determination of heroin, fentanyl, and its 10 analogs, both separately and simultaneously, using a combination of high-performance liquid chromatography with diode array detection and amperometric detection in seized street samples
  • Development of an ultra-high performance liquid chromatography-tandem mass spectrometric (UHPLC-MS/MS) technique to estimate 31 fentanyl analogs and 6 synthetic opioids in hair samples
  • Separation and quantification of fentanyl, its analogs, and synthetic opioids from whole blood samples by liquid chromatography-tandem mass spectrometry (LC-MS/MS) following their liquid-liquid extraction
  • Semi-quantitative analysis of urine and analgesic tablet slurry samples for the determination of fentanyl and norfentanyl by paper spray-mass spectrometry(PS-MS)

Features and Benefits

  • Fully characterized under ISO/IEC 17025 and ISO 17034 accreditation
  • Accompanied with a comprehensive Certificate of Analysis (CoA) with data on stability, homogeneity, accuracy of concentration, uncertainty, and traceability
  • Rigorously tested through real-time stability studies to ensure accuracy and shelf life
  • Gravimetrically prepared using qualified precision balances to ensure minimal uncertainty
  • Flame sealed under argon into ampoules for long-term shelf life
  • Offered in a convenient, DEA-exempt format to improve laboratory efficiency

Legal Information

Actiq is a registered trademark of Anesta Corp.
CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
Duragesic is a registered trademark of Johnson & Johnson
Fentora is a registered trademark of Cima Labs, Inc.
Snap-N-Shoot is a registered trademark of Cerilliant Corporation
Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

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Norfentanyl-D5 oxalate solution, 1.0 mg/mL in methanol (as free base), ampule of 1 mL, certified reference material, Cerilliant®

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A-139

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p-Fluorofentanyl solution, 100 μg/mL in methanol, certified reference material, ampule of 0.5 mL, Cerilliant®

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N-114

Norcarfentanil oxalate oxalate salt solution, 100 μg/mL in methanol (as a free base), certified reference material, ampule of 0.5 mL, Cerilliant®

V-048

Valeryl fentanyl hydrochloride solution, 100 μg/mL in methanol (as a free base), certified reference material, ampule of 0.5 mL, Cerilliant®

A-140

Acryl fentanyl hydrochloride solution, 100 μg/mL in methanol (as free base), certified reference material, ampule of 0.5 mL, Cerilliant®

O-047

Ocfentanil solution, 100 μg/mL in methanol, certified reference material, ampule of 0.5 mL, Cerilliant®

F-048

p-Fluorobutyryl fentanyl (PFBF) solution, 100 μg/mL in methanol (), certified reference material, ampule of 0.5 mL, Cerilliant®

H-130

(±)-β-Hydroxythiofentanyl hydrochloride solution, 100 μg/mL in methanol (as free base), certified reference material, ampule of 0.5 mL, Cerilliant®

D-168

N-Desmethyl U-47700-D3 solution, 100 μg/mL in acetonitrile, certified reference material, ampule of 1 mL, Cerilliant®

D-167

N-Desmethyl U-47700 solution, 1 mg/mL in acetonitrile, certified reference material, ampule of 1 mL, Cerilliant®

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4-Fluoro-isobutyryl fentanyl solution, 100 μg/mL in methanol, certified reference material, ampule of 0.5 mL, Cerilliant®

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4-ANPP-D5 solution, 100 μg/mL in methanol, certified reference material, ampule of 0.5 mL, Cerilliant®

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Methoxyacetyl fentanyl hydrochloride solution, 100 μg/mL in methanol (as free base), certified reference material, ampule of 0.5 mL, Cerilliant®

V-068

Valeryl fentanyl-D5 hydrochloride solution, 100 μg/mL in methanol (as free base), certified reference material, ampule of 0.5 mL, Cerilliant®

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A-156

Acryl fentanyl-D5 hydrochloride solution, 100 μg/mL in methanol (as free base), certified reference material, ampule of 0.5 mL, Cerilliant®

Signal Word

Danger

Hazard Classifications

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1

Target Organs

Eyes,Central nervous system

Storage Class Code

3 - Flammable liquids

WGK

WGK 2

Flash Point(F)

49.5 °F - closed cup

Flash Point(C)

9.7 °C - closed cup

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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An EMS guide to chronic pain.
Kevin T Collopy et al.
EMS world, 42(7), 59-63 (2013-08-10)
Nele Plock et al.
International journal of clinical pharmacology and therapeutics, 51(6), 495-508 (2013-04-25)
Intranasal Fentanyl Spray (INFS) was developed for the treatment of breakthrough pain (BTP) in cancer patients using a new route of administration. Dose strengths of 50, 100, and 200 μg INFS (Instanyl®) are currently on the market, however, some adult
Hong-Xia Zhu et al.
Zhongguo zhen jiu = Chinese acupuncture & moxibustion, 33(4), 342-346 (2013-07-04)
To observe the clinical effect of acupoint injection with small dose of fentanyl-droperido mixed liquor at different time stages on labor analgesia, and explore its function mechanism. One hundred and fifty cases of full-term primiparas who were intended to take
[Pain therapy. Treating pain patients with opioid preparations].
MMW Fortschritte der Medizin, 155(6), 70-71 (2013-05-25)
Esther Encinas et al.
Paediatric drugs, 15(3), 247-257 (2013-05-10)
Fentanyl is a synthetic opioid commonly used as an anesthetic and also increasingly popular as a sedative agent in neonates. Initial dosage regimens in this population are often empirically derived from adults on a body weight basis. However, ontogenic maturation
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Benefits of Ascentis Express Phenyl-Hexyl over Biphenyl for the Separation of Pain Management Opiates

Although both biphenyl and phenyl-hexyl phases can resolve these compounds, the former exhibits excellent peak shape and substantially less silanol-derived ion exchange activity.

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