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Merck

HTR5A

5-hydroxytryptamine (serotonin) receptor 5A, G protein-coupled

Synonyms:
5-HT5A
Species:
UniProtKB ID:
Gene ID:
  • Human(3361) Summary: The neurotransmitter serotonin (5-hydroxytryptamine, 5-HT) has been implicated in a wide range of psychiatric conditions and also has vasoconstrictive and vasodilatory effects. The gene described in this record is a member of 5-hydroxytryptamine (serotonin) receptor family and encodes a multi-pass membrane protein that functions as a receptor for 5-hydroxytryptamine and couples to G-proteins. This protein has been shown to function in part through the regulation of intracellular Ca2+ mobilization. [provided by RefSeq, Jul 2008]
  • Mouse(15563) 5-hydroxytryptamine (serotonin) receptor 5A
  • Rat(25689) 5-hydroxytryptamine (serotonin) receptor 5A, G protein-coupled
  • cow(541200) 5-hydroxytryptamine (serotonin) receptor 5A
  • Horse(100063709) 5-hydroxytryptamine (serotonin) receptor 5A, G protein-coupled
  • domestic cat(101084611) 5-hydroxytryptamine (serotonin) receptor 5A, G protein-coupled
  • Zebrafish(100038775) 5-hydroxytryptamine (serotonin) receptor 5A
  • dog(482814) 5-hydroxytryptamine (serotonin) receptor 5A, G protein-coupled
  • sheep(101116905) 5-hydroxytryptamine (serotonin) receptor 5A, G protein-coupled
  • naked mole-rat(101723065) 5-hydroxytryptamine (serotonin) receptor 5A, G protein-coupled
  • domestic guinea pig(100379278) 5-hydroxytryptamine (serotonin) receptor 5A
  • chicken(428409) 5-hydroxytryptamine (serotonin) receptor 5A, G protein-coupled

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Small Molecule - Agonist

Product Number
Description
Species
5-Carboxamidotryptamine maleate salt, powder, ≥98% (HPLC),
Species
human, rat
(+)-Fenfluramine hydrochloride, ,
Species
human
Quipazine maleate salt, ,
Species
human

Small Molecule - Allosteric Modulator

Product Number
Description
Species
DCEBIO, ≥98% (HPLC), solid,
Species
human

Small Molecule - Antagonist

Product Number
Description
Species
5-Carboxamidotryptamine maleate salt, powder, ≥98% (HPLC),
Species
human, rat
Amisulpride, European Pharmacopoeia (EP) Reference Standard,
Species
human
Amisulpride, ≥98% (HPLC),
Species
human
Amisulpride, British Pharmacopoeia (BP) Reference Standard,
Species
human
Amisulpride for system suitability, European Pharmacopoeia (EP) Reference Standard,
Species
human

Antibodies

Product Number
Description
Species Reactivity
Application
Anti-HTR5A (AB1) antibody produced in rabbit, affinity isolated antibody, buffered aqueous solution,
Species Reactivity
human
Application
ELISA
immunohistochemistry
Anti-HTR5A (AB2) antibody produced in rabbit, affinity isolated antibody, buffered aqueous solution,
Species Reactivity
bovine, dog, guinea pig, horse, human, monkey, mouse, rat
Application
ELISA
immunohistochemistry
Anti-HTR5A antibody produced in rabbit, affinity isolated antibody, buffered aqueous solution,
Species Reactivity
human
Application
ELISA
immunohistochemistry
Anti-HTR5A antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human
Application
ELISA
immunofluorescence

western blot

Small Molecule - Blocker

Product Number
Description
Species
Trimipramine maleate salt, ≥98% (TLC), powder,
Species
human
Zimelidine dihydrochloride, solid,
Species
human

Small Molecule - Inhibitor

Product Number
Description
Species
S-(+)-Fluoxetine hydrochloride, ≥98% (HPLC), solid,
Species
human
R-(−)-Fluoxetine hydrochloride, >98% (HPLC), solid,
Species
human
Sertraline hydrochloride, ≥98% (HPLC),
Species
human
Fluvoxamine maleate, solid,
Species
human
Reserpine, ,
Species
human

Small Molecule - Ligand

Product Number
Description
Species
Nω-Methyl-5-hydroxy­trypt­amine oxalate salt, ≥90% (HPLC),
Species
human

Small Molecule - Metabolite

Product Number
Description
Species
5-Hydroxyindole-3-acetic acid, ≥98% (HPLC), crystalline,
Species
human

Small Molecule - Precursor

Product Number
Description
Species
5-Hydroxy-L-tryptophan, powder,
Species
human

esiRNA

Product Number
Description
Species
MISSION® esiRNA, targeting human HTR5A,
Species
human