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Merck

CYP51A1

cytochrome P450, family 51, subfamily A, polypeptide 1

Synonyms:
CP51, CYP51, CYPL1, LDM, P450-14DM, P450L1
Species:
Human CYP51A1 (1595), chicken CYP51A1 (420548), dog CYP51A1 (475225), cow CYP51A1 (505060)
UniProtKB ID:
Q16850, A4D1F8, B2RAI4, B4DJ55, O00770, O00772, Q16784, Q8N1A8
Gene ID:
  • Human(1595) Summary: This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This endoplasmic reticulum protein participates in the synthesis of cholesterol by catalyzing the removal of the 14alpha-methyl group from lanosterol. Homologous genes are found in all three eukaryotic phyla, fungi, plants, and animals, suggesting that this is one of the oldest cytochrome P450 genes. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]
  • chicken(420548) cytochrome P450, family 51, subfamily A, polypeptide 1
  • dog(475225) cytochrome P450, family 51, subfamily A, polypeptide 1
  • cow(505060) cytochrome P450, family 51, subfamily A, polypeptide 1

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Antibodies

Product Number
Description
Species Reactivity
Application
HPA043508
Anti-CYP51A1 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human
Application
immunofluorescence
immunohistochemistry
SAB2107501
Anti-CYP51A1 antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
dog, guinea pig, horse, human, rat
Application
western blot
HPA041325
Anti-CYP51A1 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human
Application
immunofluorescence
immunohistochemistry
western blot

Small Molecule - Inhibitor

Product Number
Description
Species
K1003
Ketoconazole, 99.0-101.0% (EP, titration),
Species
mouse, human, rat
UC280
Ketoconazole, ,
Species
mouse, human, rat

esiRNA

Product Number
Description
Species
EHU105301
MISSION® esiRNA, targeting human CYP51A1, LRRD1,
Species
human