CDKN2A
cyclin-dependent kinase inhibitor 2A
Synonyms:
ARF, CDK4I, CDKN2, CMM2, INK4, INK4A, MLM, MTS-1, MTS1, P14, P14ARF, P16, P16-INK4A, P16INK4, P16INK4A, P19, P19ARF, TP16
Species:
Human CDKN2A (1029), Mouse Cdkn2a (12578), Rat Cdkn2a (25163), chicken CDKN2A (395077), dog CDKN2A (100271861), domestic guinea pig Cdkn2a (100731972), domestic cat CDKN2A (101089220), cow CDKN2A (616369)
UniProtKB ID:
Gene ID:
- Human(1029) Summary: This gene generates several transcript variants which differ in their first exons. At least three alternatively spliced variants encoding distinct proteins have been reported, two of which encode structurally related isoforms known to function as inhibitors of CDK4 kinase. The remaining transcript includes an alternate first exon located 20 Kb upstream of the remainder of the gene; this transcript contains an alternate open reading frame (ARF) that specifies a protein which is structurally unrelated to the products of the other variants. This ARF product functions as a stabilizer of the tumor suppressor protein p53 as it can interact with, and sequester, the E3 ubiquitin-protein ligase MDM2, a protein responsible for the degradation of p53. In spite of the structural and functional differences, the CDK inhibitor isoforms and the ARF product encoded by this gene, through the regulatory roles of CDK4 and p53 in cell cycle G1 progression, share a common functionality in cell cycle G1 control. This gene is frequently mutated or deleted in a wide variety of tumors, and is known to be an important tumor suppressor gene. [provided by RefSeq, Sep 2012]
- Mouse(12578) cyclin-dependent kinase inhibitor 2A
- Rat(25163) cyclin-dependent kinase inhibitor 2A
- chicken(395077) cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)
- dog(100271861) cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)
- domestic guinea pig(100731972) cyclin-dependent kinase inhibitor 2A
- domestic cat(101089220) cyclin-dependent kinase inhibitor 2A
- cow(616369) cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)
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Antibodies
Product Number
Description
Species Reactivity
Application
ANTI-PHOSPHO-P16-INK4A(S140) antibody produced in rabbit, affinity isolated antibody, buffered aqueous solution,
Species Reactivity
human
Application
immunohistochemistry
western blot
western blot
Anti-p14ARF (p19ARF), from rabbit, purified by affinity chromatography,
Species Reactivity
human
Application
immunohistochemistry
immunoprecipitation (IP)
western blot
immunoprecipitation (IP)
western blot
Anti-CDKN2A (Isoform 1)/P16INK4A antibody produced in goat, affinity isolated antibody, buffered aqueous solution,
Species Reactivity
human
Application
ELISA
immunohistochemistry
western blot
immunohistochemistry
western blot
Anti-p16 INK antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human, mouse
Application
ELISA
western blot
western blot
Anti-CDKN2A/p16INK4a antibody produced in rabbit, ,
Species Reactivity
human, mouse, rat
Application
immunofluorescence
immunohistochemistry
western blot
immunohistochemistry
western blot
Small Molecule - Inhibitor
Proteins
esiRNA
Product Number
Description
Species