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  • Endothelial SHIP2 Suppresses Nox2 NADPH Oxidase-Dependent Vascular Oxidative Stress, Endothelial Dysfunction, and Systemic Insulin Resistance.

Endothelial SHIP2 Suppresses Nox2 NADPH Oxidase-Dependent Vascular Oxidative Stress, Endothelial Dysfunction, and Systemic Insulin Resistance.

Diabetes (2017-08-24)
Nicole T Watt, Matthew C Gage, Peysh A Patel, Hema Viswambharan, Piruthivi Sukumar, Stacey Galloway, Nadira Y Yuldasheva, Helen Imrie, Andrew M N Walker, Kathryn J Griffin, Natalia Makava, Anna Skromna, Katherine Bridge, David J Beech, Stéphane Schurmans, Stephen B Wheatcroft, Mark T Kearney, Richard M Cubbon
PMID28830894
ABSTRACT

Shc homology 2-containing inositol 5' phosphatase-2 (SHIP2) is a lipid phosphatase that inhibits insulin signaling downstream of phosphatidylinositol 3-kinase (PI3K); its role in vascular function is poorly understood. To examine its role in endothelial cell (EC) biology, we generated mice with catalytic inactivation of one SHIP2 allele selectively in ECs (ECSHIP2