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  • Stereodivergent synthesis of enantiopure cis- and trans-3-Ethyl-4-piperidineacetates.

Stereodivergent synthesis of enantiopure cis- and trans-3-Ethyl-4-piperidineacetates.

Organic letters (2002-08-03)
Mercedes Amat, Maria Pérez, Núria Llor, Joan Bosch
PMID12153235
ABSTRACT

[reaction: see text] Starting from a common chiral bicyclic lactam 11, enantiopure trans- or cis-3-ethyl-4-piperidineacetate derivatives are obtained by conjugate addition of an enolate or a cuprate to the unsaturated lactams 12 or 18, respectively.