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  • Internal Lewis acid assisted ureas: tunable hydrogen bond donor catalysts.

Internal Lewis acid assisted ureas: tunable hydrogen bond donor catalysts.

Chemical communications (Cambridge, England) (2012-12-01)
David M Nickerson, Veronica V Angeles, Tyler J Auvil, Sonia S So, Anita E Mattson
PMID23198283
ABSTRACT

The strategic incorporation of internal Lewis acids onto urea scaffolds gives rise to a family of tunable hydrogen bond donor catalysts. The nature of the Lewis acid and associated ligands affects the urea polarization, acidity, and activity in reactions of nitrocyclopropane carboxylates and nitrodiazoesters.