- Study of standard tablet formulation based on fluidized-bed granulation.
Study of standard tablet formulation based on fluidized-bed granulation.
Drug development and industrial pharmacy (1999-01-07)
H Sunada, M Hasegawa, T Makino, H Sakamoto, K Fujita, T Tanino, H Kokubo, T Kawaguchi
PMID9876579
ABSTRACT
In this study, acetaminophen, ascorbic acid, and ethenzamide were selected as model drugs for tableting granules. Agitation and fluidized-bed granulation were carried out at three drug contents of 30, 50, and 70%. Compared with agitation granulation, granules made by fluidized-bed granulation showed superior compressibility with wide formulation allowance for drug type and amount. Fluidized-bed granulation resulted in less granule hardness and greater plastic deformability. The granules had considerable compactness and for tablets containing 70% ethenzamide, prolonged disintegration and dissolution times were noted. These are typical features of granules produced by fluidized-bed granulation.
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