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Enhancement of rectal absorption of insulin using salicylates in dogs.

The Journal of pharmacy and pharmacology (1983-03-01)
T Nishihata, J H Rytting, A Kamada, T Higuchi, M Routh, L Caldwell
ABSTRACT

Sodium salicylate and 5-methoxysalicylate both increased the rectal absorption of insulin in dogs when co-administered with insulin in various formulations. Microenema formulations containing 4% gelatin showed the highest insulin bioavailability of the formulations studied whereas microenemas (without gelatin) and suppository formulations were not as effective in enhancing the rectal absorption of insulin.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
2-Hydroxy-5-methoxybenzoic acid, 98%