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Merck

Total synthesis of kottamide E.

Chemical communications (Cambridge, England) (2013-02-12)
Thomas B Parsons, Neil Spencer, Chi W Tsang, Richard S Grainger
ABSTRACT

The first synthesis of kottamide E, a marine natural product containing a 5,6-dibromoindole linked via a (Z)-enamide to an unusual 1,2-dithiolane-containing amino acid, is reported.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
Indole, ≥99%, FG
Sigma-Aldrich
4-Nitrophenyl 2-(trimethylsilyl)ethyl carbonate, ≥97.0%
Sigma-Aldrich
Indole, ≥99%
Supelco
Indole, analytical standard