- New topoisomerases inhibitors: synthesis of rutaecarpine derivatives and their inhibitory activity against topoisomerases.
New topoisomerases inhibitors: synthesis of rutaecarpine derivatives and their inhibitory activity against topoisomerases.
Archives of pharmacal research (2012-05-31)
Seung Ill Kim, Seung Ho Lee, Eung-Seok Lee, Chong-Soon Lee, Yurngdong Jahng
PMID22644846
ABSTRACT
A series of rutaecarpine derivatives were prepared by employing previously reported methods and their inhibitory activities against topoisomerase I and II were evaluated. Among them, strongly cytotoxic 10-bromorutaecarpine and 3-chlororutaecarpine showed strong inhibitory activities against topo I and II.
MATERIALS