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  • New topoisomerases inhibitors: synthesis of rutaecarpine derivatives and their inhibitory activity against topoisomerases.

New topoisomerases inhibitors: synthesis of rutaecarpine derivatives and their inhibitory activity against topoisomerases.

Archives of pharmacal research (2012-05-31)
Seung Ill Kim, Seung Ho Lee, Eung-Seok Lee, Chong-Soon Lee, Yurngdong Jahng
ABSTRACT

A series of rutaecarpine derivatives were prepared by employing previously reported methods and their inhibitory activities against topoisomerase I and II were evaluated. Among them, strongly cytotoxic 10-bromorutaecarpine and 3-chlororutaecarpine showed strong inhibitory activities against topo I and II.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
Rutaecarpine, >98% (HPLC)