- Simplified synthesis of isotopically labeled 5,5-dimethyl-pyrroline N-oxide.
Simplified synthesis of isotopically labeled 5,5-dimethyl-pyrroline N-oxide.
Molecules (Basel, Switzerland) (2011-10-12)
Fabian Leinisch, Jinjie Jiang, Leesa J Deterding, Ronald P Mason
PMID21986521
ABSTRACT
5,5-Dimethylpyrroline N-oxide (15N) and 5,5-di(trideuteromethyl)pyrroline N-oxide were synthesized from the respective isotopically labeled 2-nitropropane analogs obtained from the reaction of sodium nitrate with 2-halopropanes. This facile, straightforward process allows synthesizing isotopically labeled DMPO analogs in a 4-step reaction without special equipment.
MATERIALS