- Increasing the efficacy of bioorthogonal click reactions for bioconjugation: a comparative study.
Increasing the efficacy of bioorthogonal click reactions for bioconjugation: a comparative study.
Angewandte Chemie (International ed. in English) (2011-07-16)
Christen Besanceney-Webler, Hao Jiang, Tianqing Zheng, Lei Feng, David Soriano del Amo, Wei Wang, Liana M Klivansky, Florence L Marlow, Yi Liu, Peng Wu
PMID21761519
ABSTRACT
Raising the bar: the efficacy of bioorthogonal reactions for bioconjugation has been thoroughly evaluated in four different biological settings. Powered by the development of new biocompatible ligands, the copper-catalyzed azide-alkyne cycloaddition has brought about unsurpassed bioconjugation efficiency, and thus it holds great promise as a highly potent and adaptive tool for a broader spectrum of biological applications.