USP18
ubiquitin specific peptidase 18
Synonyms:
ISG43, UBP43
Species:
Human USP18 (11274), Mouse Usp18 (24110), Rat Usp18 (312688), chicken USP18 (418167), dog USP18 (486763), Horse USP18 (100054488), cow USP18 (515202), naked mole-rat Usp18 (101708130), domestic guinea pig Usp18 (100729301), domestic cat USP18 (101093867)
UniProtKB ID:
Gene ID:
- Human(11274) Summary: The protein encoded by this gene belongs to the ubiquitin-specific proteases (UBP) family of enzymes that cleave ubiquitin from ubiquitinated protein substrates. It is highly expressed in liver and thymus, and is localized to the nucleus. This protein efficiently cleaves only ISG15 (a ubiquitin-like protein) fusions, and deletion of this gene in mice results in a massive increase of ISG15 conjugates in tissues, indicating that this protein is a major ISG15-specific protease. Mice lacking this gene are also hypersensitive to interferon, suggesting a function of this protein in downregulating interferon responses, independent of its isopeptidase activity towards ISG15. [provided by RefSeq, Sep 2011]
- Mouse(24110) ubiquitin specific peptidase 18
- Rat(312688) ubiquitin specific peptidase 18
- chicken(418167) ubiquitin specific peptidase 18
- dog(486763) ubiquitin specific peptidase 18
- Horse(100054488) ubiquitin specific peptidase 18
- cow(515202) ubiquitin specific peptidase 18
- naked mole-rat(101708130) ubiquitin specific peptidase 18
- domestic guinea pig(100729301) ubiquitin specific peptidase 18
- domestic cat(101093867) ubiquitin specific peptidase 18
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Antibodies
Product Number
Description
Species Reactivity
Application
Anti-USP18 antibody produced in mouse, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
immunofluorescence
western blot
western blot