SLC12A3
solute carrier family 12 (sodium/chloride transporter), member 3
Synonyms:
NCC, NCCT, TSC
Species:
Human SLC12A3 (6559), Mouse Slc12a3 (20497), Rat Slc12a3 (54300), sheep SLC12A3 (101120940), domestic guinea pig Slc12a3 (100726300), naked mole-rat Slc12a3 (101704301), Zebrafish slc12a3 (565439), chicken SLC12A3 (415692), dog SLC12A3 (478118), domestic cat SLC12A3 (101082284) ...More
UniProtKB ID:
Gene ID:
- Human(6559) Summary: This gene encodes a renal thiazide-sensitive sodium-chloride cotransporter that is important for electrolyte homeostasis. This cotransporter mediates sodium and chloride reabsorption in the distal convoluted tubule. Mutations in this gene cause Gitelman syndrome, a disease similar to Bartter's syndrome, that is characterized by hypokalemic alkalosis combined with hypomagnesemia, low urinary calcium, and increased renin activity associated with normal blood pressure. This cotransporter is the target for thiazide diuretics that are used for treating high blood pressure. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
- Mouse(20497) solute carrier family 12, member 3
- Rat(54300) solute carrier family 12 (sodium/chloride transporter), member 3
- sheep(101120940) solute carrier family 12 (sodium/chloride transporters), member 3
- domestic guinea pig(100726300) solute carrier family 12 (sodium/chloride transporters), member 3
- naked mole-rat(101704301) solute carrier family 12 (sodium/chloride transporters), member 3
- Zebrafish(565439) solute carrier family 12 (sodium/chloride transporters), member 3
- chicken(415692) solute carrier family 12 (sodium/chloride transporters), member 3
- dog(478118) solute carrier family 12 (sodium/chloride transporters), member 3
- domestic cat(101082284) solute carrier family 12 (sodium/chloride transporters), member 3
- cow(404171) solute carrier family 12 (sodium/chloride transporters), member 3
- Horse(100051953) solute carrier family 12 (sodium/chloride transporters), member 3
Custom & Knockdown Gene Products
siRNA
Shop predesigned siRNA that are designed using the proprietary Rosetta Inpharmatics algorithm.
shRNA
Shop the largest, most validated shRNA collection and build your own clone sets.
Custom Gene Products
We offer a comprehensive portfolio of DNA oligos, RNA oligos and predesigned primers.
Antibodies
Product Number
Description
Species Reactivity
Application
Anti-SLC12A3 antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
bovine, dog, guinea pig, horse, human, rabbit, rat
Application
western blot
Anti-Thiazide-Sensitive NaCl Cotransporter Antibody, Chemicon®, from rabbit,
Species Reactivity
human, mouse, rabbit, rat
Application
immunohistochemistry
western blot
western blot
Anti-SLC12A3 antibody produced in rabbit, 1 mg/mL, affinity isolated antibody,
Species Reactivity
human, mouse, rat
Application
western blot
Small Molecule - Inhibitor
Product Number
Description
Species
Chlorothiazide, Pharmaceutical Secondary Standard; Certified Reference Material,
Species
human