Skip to Content
Merck

RP1

retinitis pigmentosa 1 (autosomal dominant)

Synonyms:
DCDC4A, ORP1
Species:
Human RP1 (6101), Mouse Rp1 (19888), Rat Rp1 (681377), Thale Cress RP1 (840916), Thale Cress RP1 (827869), dog RP1 (403565), cow RP1 (280916), Horse RP1 (100053179), sheep RP1 (101114620), Domestic Rabbit RP1 (100355685) ...More
UniProtKB ID:
P56715
Gene ID:
  • Human(6101) Summary: This gene encodes a member of the doublecortin family. The protein encoded by this gene contains two doublecortin domains, which bind microtubules and regulate microtubule polymerization. The encoded protein is a photoreceptor microtubule-associated protein and is required for correct stacking of outer segment disc. This protein and the RP1L1 protein, another retinal-specific protein, play essential and synergistic roles in affecting photosensitivity and outer segment morphogenesis of rod photoreceptors. Because of its response to in vivo retinal oxygen levels, this protein was initially named ORP1 (oxygen-regulated protein-1). This protein was subsequently designated RP1 (retinitis pigmentosa 1) when it was found that mutations in this gene cause autosomal dominant retinitis pigmentosa. Mutations in this gene also cause autosomal recessive retinitis pigmentosa. Transcript variants resulted from an alternative promoter and alternative splicings have been found, which overlap the current reference sequence and has several exons upstream and downstream of the current reference sequence. However, the biological validity and full-length nature of some variants cannot be determined at this time.[provided by RefSeq, Sep 2010]
  • Mouse(19888) retinitis pigmentosa 1 (human)
  • Rat(681377) retinitis pigmentosa 1 (human)
  • Thale Cress(840916) 60S ribosomal protein L3-1
  • Thale Cress(827869) pyruvate, phosphate dikinase regulatory protein 1
  • dog(403565) retinitis pigmentosa 1 (autosomal dominant)
  • cow(280916) retinitis pigmentosa 1 (autosomal dominant)
  • Horse(100053179) retinitis pigmentosa 1 (autosomal dominant)
  • sheep(101114620) retinitis pigmentosa 1 (autosomal dominant)
  • Domestic Rabbit(100355685) retinitis pigmentosa 1 (autosomal dominant)
  • domestic guinea pig(100715117) retinitis pigmentosa 1 (autosomal dominant)
  • naked mole-rat(101708003) retinitis pigmentosa 1 (autosomal dominant)

Custom & Knockdown Gene Products

  • siRNA

    Shop predesigned siRNA that are designed using the proprietary Rosetta Inpharmatics algorithm.

  • shRNA

    Shop the largest, most validated shRNA collection and build your own clone sets.

  • Custom Gene Products

    We offer a comprehensive portfolio of DNA oligos, RNA oligos and predesigned primers.