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Merck

PTPN12

protein tyrosine phosphatase, non-receptor type 12

Synonyms:
PTP-PEST, PTPG1
Species:
Human PTPN12 (5782), Mouse Ptpn12 (19248), Rat Ptpn12 (117255), chicken PTPN12 (417725), cow PTPN12 (531877), sheep PTPN12 (101117497), Zebrafish ptpn12 (393642), Horse PTPN12 (100057833), domestic guinea pig Ptpn12 (100725572), domestic cat PTPN12 (101091096) ...More
UniProtKB ID:
Q05209, B4DKY2, E9PEH9, Q16130, Q59FD6, Q75MN8, Q86XU4
Gene ID:
  • Human(5782) Summary: The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains a C-terminal PEST motif, which serves as a protein-protein interaction domain, and may regulate protein intracellular half-life. This PTP was found to bind and dephosphorylate the product of the oncogene c-ABL and thus may play a role in oncogenesis. This PTP was also shown to interact with, and dephosphorylate, various products related to cytoskeletal structure and cell adhesion, such as p130 (Cas), CAKbeta/PTK2B, PSTPIP1, and paxillin. This suggests it has a regulatory role in controlling cell shape and mobility. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Oct 2008]
  • Mouse(19248) protein tyrosine phosphatase, non-receptor type 12
  • Rat(117255) protein tyrosine phosphatase, non-receptor type 12
  • chicken(417725) protein tyrosine phosphatase, non-receptor type 12
  • cow(531877) protein tyrosine phosphatase, non-receptor type 12
  • sheep(101117497) protein tyrosine phosphatase, non-receptor type 12
  • Zebrafish(393642) protein tyrosine phosphatase, non-receptor type 12
  • Horse(100057833) protein tyrosine phosphatase, non-receptor type 12
  • domestic guinea pig(100725572) protein tyrosine phosphatase, non-receptor type 12
  • domestic cat(101091096) protein tyrosine phosphatase, non-receptor type 12
  • dog(483277) protein tyrosine phosphatase, non-receptor type 12
  • Domestic Rabbit(100350817) protein tyrosine phosphatase, non-receptor type 12
  • naked mole-rat(101697685) protein tyrosine phosphatase, non-receptor type 12

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Antibodies

Product Number
Description
Species Reactivity
Application
05-1417
Anti-PTP-PEST Antibody, clone AG25, ascites fluid, clone AG25, from mouse,
Species Reactivity
human, mouse, rat
Application
immunocytochemistry
immunoprecipitation (IP)
western blot
P9109
Monoclonal Anti-Protein Tyrosine Phosphatase PEST antibody produced in mouse, clone AG25, purified immunoglobulin,
Species Reactivity
bovine, human, mouse, rat
Application
immunoprecipitation (IP)
western blot

Proteins

Product Number
Description
Species
SRP5073
PTPN12 (1-355), active, GST tagged human, recombinant, expressed in E. coli, ≥70% (SDS-PAGE), buffered aqueous glycerol solution,
Species
human