PTP4A2
protein tyrosine phosphatase type IVA, member 2
Synonyms:
HH13, HH7-2, HU-PP-1, OV-1, PRL-2, PRL2, PTP4A, PTPCAAX2, ptp-IV1a, ptp-IV1b
Species:
Human PTP4A2 (8073), Mouse Ptp4a2 (19244), Rat Ptp4a2 (85237), domestic cat PTP4A2 (101097001), cow PTP4A2 (614435), sheep PTP4A2 (101118084), domestic guinea pig Ptp4a2 (100731020), naked mole-rat Ptp4a2 (101707478), Zebrafish ptp4a2 (334483), chicken PTP4A2 (419649)
UniProtKB ID:
Gene ID:
- Human(8073) Summary: The protein encoded by this gene belongs to a small class of the protein tyrosine phosphatase (PTP) family. PTPs are cell signaling molecules that play regulatory roles in a variety of cellular processes. PTPs in this class contain a protein tyrosine phosphatase catalytic domain and a characteristic C-terminal prenylation motif. This PTP has been shown to primarily associate with plasmic and endosomal membrane through its C-terminal prenylation. This PTP was found to interact with the beta-subunit of Rab geranylgeranyltransferase II (beta GGT II), and thus may function as a regulator of GGT II activity. Overexpression of this gene in mammalian cells conferred a transformed phenotype, which suggested its role in tumorigenesis. Alternatively spliced transcript variants have been described. Related pseudogenes exist on chromosomes 11, 12 and 17. [provided by RefSeq, Aug 2010]
- Mouse(19244) protein tyrosine phosphatase 4a2
- Rat(85237) protein tyrosine phosphatase 4a2
- domestic cat(101097001) protein tyrosine phosphatase type IVA, member 2
- cow(614435) protein tyrosine phosphatase type IVA, member 2
- sheep(101118084) protein tyrosine phosphatase type IVA, member 2
- domestic guinea pig(100731020) protein tyrosine phosphatase type IVA, member 2
- naked mole-rat(101707478) protein tyrosine phosphatase type IVA, member 2
- Zebrafish(334483) protein tyrosine phosphatase type IVA, member 2
- chicken(419649) protein tyrosine phosphatase type IVA, member 2
- dog(609835) protein tyrosine phosphatase type IVA, member 2
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