PSMC2
proteasome (prosome, macropain) 26S subunit, ATPase, 2
Synonyms:
MSS1, Nbla10058, S7
Species:
Human PSMC2 (5701), Mouse Psmc2 (19181), Rat Psmc2 (25581), Horse PSMC2 (100058456), Zebrafish psmc2 (393941), chicken PSMC2 (417716), domestic guinea pig Psmc2 (100723641), naked mole-rat Psmc2 (101721422), sheep PSMC2 (101119977), cow PSMC2 (530186) ...More
UniProtKB ID:
Gene ID:
- Human(5701) Summary: The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the ATPase subunits, a member of the triple-A family of ATPases which have a chaperone-like activity. This subunit has been shown to interact with several of the basal transcription factors so, in addition to participation in proteasome functions, this subunit may participate in the regulation of transcription. This subunit may also compete with PSMC3 for binding to the HIV tat protein to regulate the interaction between the viral protein and the transcription complex. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Mar 2011]
- Mouse(19181) proteasome (prosome, macropain) 26S subunit, ATPase 2
- Rat(25581) proteasome (prosome, macropain) 26S subunit, ATPase 2
- Horse(100058456) proteasome (prosome, macropain) 26S subunit, ATPase, 2
- Zebrafish(393941) proteasome (prosome, macropain) 26S subunit, ATPase 2
- chicken(417716) proteasome (prosome, macropain) 26S subunit, ATPase, 2
- domestic guinea pig(100723641) proteasome (prosome, macropain) 26S subunit, ATPase, 2
- naked mole-rat(101721422) proteasome (prosome, macropain) 26S subunit, ATPase, 2
- sheep(101119977) proteasome (prosome, macropain) 26S subunit, ATPase, 2
- cow(530186) proteasome (prosome, macropain) 26S subunit, ATPase, 2
- domestic cat(101086215) proteasome (prosome, macropain) 26S subunit, ATPase, 2
- dog(475896) proteasome (prosome, macropain) 26S subunit, ATPase, 2
Custom & Knockdown Gene Products
siRNA
Shop predesigned siRNA that are designed using the proprietary Rosetta Inpharmatics algorithm.
shRNA
Shop the largest, most validated shRNA collection and build your own clone sets.
Custom Gene Products
We offer a comprehensive portfolio of DNA oligos, RNA oligos and predesigned primers.