PSMC1
proteasome (prosome, macropain) 26S subunit, ATPase, 1
Synonyms:
P26S4, S4, p56
Species:
Human PSMC1 (5700), Mouse Psmc1 (19179), Rat Psmc1 (117263), Horse PSMC1 (100062573), chicken PSMC1 (395804), domestic guinea pig Psmc1 (100733985), naked mole-rat Psmc1 (101698658), sheep PSMC1 (101120165), domestic cat PSMC1 (101094025), cow PSMC1 (506238)
UniProtKB ID:
Gene ID:
- Human(5700) Summary: The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the ATPase subunits, a member of the triple-A family of ATPases which have a chaperone-like activity. This subunit and a 20S core alpha subunit interact specifically with the hepatitis B virus X protein, a protein critical to viral replication. This subunit also interacts with the adenovirus E1A protein and this interaction alters the activity of the proteasome. Finally, this subunit interacts with ataxin-7, suggesting a role for the proteasome in the development of spinocerebellar ataxia type 7, a progressive neurodegenerative disorder. [provided by RefSeq, Jul 2008]
- Mouse(19179) protease (prosome, macropain) 26S subunit, ATPase 1
- Rat(117263) proteasome (prosome, macropain) 26S subunit, ATPase, 1
- Horse(100062573) proteasome (prosome, macropain) 26S subunit, ATPase, 1
- chicken(395804) proteasome (prosome, macropain) 26S subunit, ATPase, 1
- domestic guinea pig(100733985) proteasome (prosome, macropain) 26S subunit, ATPase, 1
- naked mole-rat(101698658) proteasome (prosome, macropain) 26S subunit, ATPase, 1
- sheep(101120165) proteasome (prosome, macropain) 26S subunit, ATPase, 1
- domestic cat(101094025) proteasome (prosome, macropain) 26S subunit, ATPase, 1
- cow(506238) proteasome (prosome, macropain) 26S subunit, ATPase, 1
- dog(100688636) proteasome (prosome, macropain) 26S subunit, ATPase, 1
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Antibodies
Product Number
Description
Species Reactivity
Application
Anti-PSMC1 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human
Application
immunofluorescence
immunohistochemistry
western blot
immunohistochemistry
western blot
Anti-PSMC1 antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
bovine, dog, guinea pig, horse, human, mouse, rabbit, rat
Application
western blot
Small Molecule - Inhibitor
Product Number
Description
Species