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Merck

PSMB10

proteasome (prosome, macropain) subunit, beta type, 10

Synonyms:
LMP10, MECL1, beta2i
Species:
Human PSMB10 (5699), Mouse Psmb10 (19171), Rat Psmb10 (291983), domestic cat PSMB10 (101082199), naked mole-rat Psmb10 (101701334), dog PSMB10 (489749), domestic guinea pig Psmb10 (100730197), Zebrafish psmb10 (64280), sheep PSMB10 (101116929), cow PSMB10 (282328)
UniProtKB ID:
P40306, B2R5J4, Q5U098
Gene ID:
  • Human(5699) Summary: The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the proteasome B-type family, also known as the T1B family, that is a 20S core beta subunit. Proteolytic processing is required to generate a mature subunit. Expression of this gene is induced by gamma interferon, and this gene product replaces catalytic subunit 2 (proteasome beta 7 subunit) in the immunoproteasome. [provided by RefSeq, Jul 2008]
  • Mouse(19171) proteasome (prosome, macropain) subunit, beta type 10
  • Rat(291983) proteasome (prosome, macropain) subunit, beta type 10
  • domestic cat(101082199) proteasome (prosome, macropain) subunit, beta type, 10
  • naked mole-rat(101701334) proteasome (prosome, macropain) subunit, beta type, 10
  • dog(489749) proteasome (prosome, macropain) subunit, beta type, 10
  • domestic guinea pig(100730197) proteasome (prosome, macropain) subunit, beta type, 10
  • Zebrafish(64280) proteasome (prosome, macropain) subunit, beta type, 10
  • sheep(101116929) proteasome (prosome, macropain) subunit, beta type, 10
  • cow(282328) proteasome (prosome, macropain) subunit, beta type, 10

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