P4HA1
prolyl 4-hydroxylase, alpha polypeptide I
Synonyms:
P4HA
Species:
Human P4HA1 (5033), Mouse P4ha1 (18451), Rat P4ha1 (64475), Domestic Rabbit P4HA1 (100340270), naked mole-rat P4ha1 (101702867), chicken P4HA1 (423704), domestic guinea pig P4ha1 (100716746), sheep P4HA1 (101116374), dog P4HA1 (479242), domestic cat P4HA1 (101096846)
UniProtKB ID:
Gene ID:
- Human(5033) Summary: This gene encodes a component of prolyl 4-hydroxylase, a key enzyme in collagen synthesis composed of two identical alpha subunits and two beta subunits. The encoded protein is one of several different types of alpha subunits and provides the major part of the catalytic site of the active enzyme. In collagen and related proteins, prolyl 4-hydroxylase catalyzes the formation of 4-hydroxyproline that is essential to the proper three-dimensional folding of newly synthesized procollagen chains. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
- Mouse(18451) procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha 1 polypeptide
- Rat(64475) prolyl 4-hydroxylase, alpha polypeptide I
- Domestic Rabbit(100340270) prolyl 4-hydroxylase, alpha polypeptide I
- naked mole-rat(101702867) prolyl 4-hydroxylase, alpha polypeptide I
- chicken(423704) prolyl 4-hydroxylase, alpha polypeptide I
- domestic guinea pig(100716746) prolyl 4-hydroxylase, alpha polypeptide I
- sheep(101116374) prolyl 4-hydroxylase, alpha polypeptide I
- dog(479242) prolyl 4-hydroxylase, alpha polypeptide I
- domestic cat(101096846) prolyl 4-hydroxylase, alpha polypeptide I
- cow(518288) prolyl 4-hydroxylase, alpha polypeptide I
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