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Merck

MECP2

methyl CpG binding protein 2 (Rett syndrome)

Synonyms:
AUTSX3, MRX16, MRX79, MRXS13, MRXSL, PPMX, RS, RTS, RTT
Species:
Human MECP2 (4204), Mouse Mecp2 (17257), Rat Mecp2 (29386), domestic cat MECP2 (101082385), Zebrafish mecp2 (335250), Domestic Rabbit MECP2 (100328751), dog MECP2 (612973), domestic guinea pig Mecp2 (100734864), sheep MECP2 (101121154), naked mole-rat Mecp2 (101700584)
UniProtKB ID:
P51608, O15233, Q6QHH9, Q7Z384
Gene ID:
  • Human(4204) Summary: DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD). Each of these proteins, with the exception of MBD3, is capable of binding specifically to methylated DNA. MECP2, MBD1 and MBD2 can also repress transcription from methylated gene promoters. In contrast to other MBD family members, MECP2 is X-linked and subject to X inactivation. MECP2 is dispensible in stem cells, but is essential for embryonic development. MECP2 gene mutations are the cause of most cases of Rett syndrome, a progressive neurologic developmental disorder and one of the most common causes of mental retardation in females. [provided by RefSeq, Jul 2009]
  • Mouse(17257) methyl CpG binding protein 2
  • Rat(29386) methyl CpG binding protein 2
  • domestic cat(101082385) methyl CpG binding protein 2 (Rett syndrome)
  • Zebrafish(335250) methyl CpG binding protein 2
  • Domestic Rabbit(100328751) methyl CpG binding protein 2 (Rett syndrome)
  • dog(612973) methyl CpG binding protein 2 (Rett syndrome)
  • domestic guinea pig(100734864) methyl CpG binding protein 2 (Rett syndrome)
  • sheep(101121154) methyl CpG binding protein 2 (Rett syndrome)
  • naked mole-rat(101700584) methyl CpG binding protein 2 (Rett syndrome)
  • cow(539629) methyl CpG binding protein 2 (Rett syndrome)

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Antibodies

Product Number
Description
Species Reactivity
Application
WH0004204M1
Monoclonal Anti-MECP2 antibody produced in mouse, clone 4B6, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
mouse
Application
ELISA
immunohistochemistry
western blot
07-013
Anti-MeCP2 Antibody, Upstate®, from rabbit,
Species Reactivity
mouse, rat
Application
western blot
M7443
Anti-MeCP2 antibody, Mouse monoclonal, clone Men-8, purified from hybridoma cell culture,
Species Reactivity
human, monkey, mouse, rat
Application
ELISA
immunocytochemistry
microarray
western blot
M6818
Anti-MeCP2 antibody, Mouse monoclonal, clone Mec-168, purified from hybridoma cell culture,
Species Reactivity
human, mouse, rat
Application
ELISA
immunocytochemistry
microarray
western blot
M9317
Anti-MeCP2 antibody produced in rabbit, ~0.6 mg/mL, affinity isolated antibody, buffered aqueous solution,
Species Reactivity
human
Application
microarray
western blot