MAPKAPK5
mitogen-activated protein kinase-activated protein kinase 5
Synonyms:
MAPKAP-K5, MK-5, MK5, PRAK
Species:
Human MAPKAPK5 (8550), Mouse Mapkapk5 (17165), Rat Mapkapk5 (498183), naked mole-rat Mapkapk5 (101703557), cow MAPKAPK5 (535625), Zebrafish mapkapk5 (436608), dog MAPKAPK5 (477480), domestic guinea pig Mapkapk5 (100730794), sheep MAPKAPK5 (101116258), domestic cat MAPKAPK5 (101082699) ...More
UniProtKB ID:
Gene ID:
- Human(8550) Summary: The protein encoded by this gene is a tumor suppressor and member of the serine/threonine kinase family. In response to cellular stress and proinflammatory cytokines, this kinase is activated through its phosphorylation by MAP kinases including MAPK1/ERK, MAPK14/p38-alpha, and MAPK11/p38-beta. The encoded protein is found in the nucleus but translocates to the cytoplasm upon phosphorylation and activation. This kinase phosphorylates heat shock protein HSP27 at its physiologically relevant sites. Two alternately spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Nov 2012]
- Mouse(17165) MAP kinase-activated protein kinase 5
- Rat(498183) mitogen-activated protein kinase-activated protein kinase 5
- naked mole-rat(101703557) mitogen-activated protein kinase-activated protein kinase 5
- cow(535625) mitogen-activated protein kinase-activated protein kinase 5
- Zebrafish(436608) mitogen-activated protein kinase-activated protein kinase 5
- dog(477480) mitogen-activated protein kinase-activated protein kinase 5
- domestic guinea pig(100730794) mitogen-activated protein kinase-activated protein kinase 5
- sheep(101116258) mitogen-activated protein kinase-activated protein kinase 5
- domestic cat(101082699) mitogen-activated protein kinase-activated protein kinase 5
- chicken(373929) mitogen-activated protein kinase-activated protein kinase 5
- Horse(100057579) mitogen-activated protein kinase-activated protein kinase 5
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