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Merck

MAPK8IP1

mitogen-activated protein kinase 8 interacting protein 1

Synonyms:
IB1, JIP-1, JIP1, PRKM8IP
Species:
Human MAPK8IP1 (9479), Mouse Mapk8ip1 (19099), Rat Mapk8ip1 (116457), domestic cat MAPK8IP1 (101085070), domestic guinea pig Mapk8ip1 (100725179), chicken MAPK8IP1 (423202), sheep MAPK8IP1 (101116934), cow MAPK8IP1 (524806), dog MAPK8IP1 (483640), Horse MAPK8IP1 (100056764)
UniProtKB ID:
Q9UQF2, D3DQP4, O43407
Gene ID:
  • Human(9479) Summary: This gene encodes a regulator of the pancreatic beta-cell function. It is highly similar to JIP-1, a mouse protein known to be a regulator of c-Jun amino-terminal kinase (Mapk8). This protein has been shown to prevent MAPK8 mediated activation of transcription factors, and to decrease IL-1 beta and MAP kinase kinase 1 (MEKK1) induced apoptosis in pancreatic beta cells. This protein also functions as a DNA-binding transactivator of the glucose transporter GLUT2. RE1-silencing transcription factor (REST) is reported to repress the expression of this gene in insulin-secreting beta cells. This gene is found to be mutated in a type 2 diabetes family, and thus is thought to be a susceptibility gene for type 2 diabetes. [provided by RefSeq, May 2011]
  • Mouse(19099) mitogen-activated protein kinase 8 interacting protein 1
  • Rat(116457) mitogen-activated protein kinase 8 interacting protein 1
  • domestic cat(101085070) mitogen-activated protein kinase 8 interacting protein 1
  • domestic guinea pig(100725179) mitogen-activated protein kinase 8 interacting protein 1
  • chicken(423202) mitogen-activated protein kinase 8 interacting protein 1
  • sheep(101116934) mitogen-activated protein kinase 8 interacting protein 1
  • cow(524806) mitogen-activated protein kinase 8 interacting protein 1
  • dog(483640) mitogen-activated protein kinase 8 interacting protein 1
  • Horse(100056764) mitogen-activated protein kinase 8 interacting protein 1
  • naked mole-rat(101705667) mitogen-activated protein kinase 8 interacting protein 1

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Antibodies

Product Number
Description
Species Reactivity
Application
SAB4503651
Anti-JIP1 antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human, mouse, rat
Application
ELISA
immunofluorescence
immunohistochemistry
western blot
HPA079657
Anti-MAPK8IP1 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human
Application
immunofluorescence
immunohistochemistry