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Merck

LMNA

lamin A/C

Synonyms:
CDCD1, CDDC, CMD1A, CMT2B1, EMD2, FPL, FPLD, FPLD2, HGPS, IDC, LDP1, LFP, LGMD1B, LMN1, LMNC, LMNL1, PRO1
Species:
Human LMNA (4000), Mouse Lmna (16905), Rat Lmna (60374), domestic guinea pig Lmna (100735212), chicken LMNA (415464), sheep LMNA (101107924), cow LMNA (404144), domestic cat LMNA (101086199), Horse LMNA (100057663), dog LMNA (480124) ...More
UniProtKB ID:
P02545, B4DI32, D3DVB0, E7EUI9, P02546, Q5TCJ2, Q5TCJ3, Q969I8
Gene ID:
  • Human(4000) Summary: The nuclear lamina consists of a two-dimensional matrix of proteins located next to the inner nuclear membrane. The lamin family of proteins make up the matrix and are highly conserved in evolution. During mitosis, the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. Lamin proteins are thought to be involved in nuclear stability, chromatin structure and gene expression. Vertebrate lamins consist of two types, A and B. Alternative splicing results in multiple transcript variants. Mutations in this gene lead to several diseases: Emery-Dreifuss muscular dystrophy, familial partial lipodystrophy, limb girdle muscular dystrophy, dilated cardiomyopathy, Charcot-Marie-Tooth disease, and Hutchinson-Gilford progeria syndrome. [provided by RefSeq, Apr 2012]
  • Mouse(16905) lamin A
  • Rat(60374) lamin A/C
  • domestic guinea pig(100735212) lamin A/C
  • chicken(415464) lamin A/C
  • sheep(101107924) lamin A/C
  • cow(404144) lamin A/C
  • domestic cat(101086199) lamin A/C
  • Horse(100057663) lamin A/C
  • dog(480124) lamin A/C
  • Zebrafish(195815) lamin A
  • naked mole-rat(101704567) lamin A/C

Custom & Knockdown Gene Products

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  • Custom Gene Products

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Antibodies

Product Number
Description
Species Reactivity
Application
SAB4501764
Anti-Lamin A antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human, mouse, rat
Application
ELISA
immunofluorescence
immunohistochemistry
western blot
L3544
Anti-Lamin A−Atto 647N antibody produced in rabbit, 1.5-3 mg/mL, affinity isolated antibody, buffered aqueous solution,
Species Reactivity
human
Application
immunofluorescence
05-714
Anti-Lamin A/C Antibody, clone 14, clone 14, Upstate®, from mouse,
Species Reactivity
canine, chicken, human, mouse, rat
Application
immunocytochemistry
western blot
SAB4200272
Anti-Progerin antibody, Mouse monoclonal, clone 13A4, purified from hybridoma cell culture,
Species Reactivity
human
Application
immunofluorescence
immunoprecipitation (IP)
western blot
SAB4503932
Anti-phospho-Lamin A/C (pSer392) antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human, mouse, rat
Application
ELISA
immunofluorescence
immunohistochemistry
western blot

esiRNA

Product Number
Description
Species
EHU063791
MISSION® esiRNA, targeting human LMNA,
Species
human