Skip to Content
Merck

HNMT

histamine N-methyltransferase

Synonyms:
HMT, HNMT-S1, HNMT-S2
Species:
Human HNMT (3176), Mouse Hnmt (140483), Rat Hnmt (81676), chicken HNMT (424298), Zebrafish hnmt (445242), domestic cat HNMT (101093704), dog HNMT (476133), sheep HNMT (641310), cow HNMT (613413), domestic guinea pig Hnmt (100135537)
UniProtKB ID:
P50135, B2R9J3, Q546Z6, Q7Z7I2, Q8IU56, Q8WW98, Q9BRW6
Gene ID:
  • Human(3176) Summary: In mammals, histamine is metabolized by two major pathways: N(tau)-methylation via histamine N-methyltransferase and oxidative deamination via diamine oxidase. This gene encodes the first enzyme which is found in the cytosol and uses S-adenosyl-L-methionine as the methyl donor. In the mammalian brain, the neurotransmitter activity of histamine is controlled by N(tau)-methylation as diamine oxidase is not found in the central nervous system. A common genetic polymorphism affects the activity levels of this gene product in red blood cells. Multiple alternatively spliced transcript variants that encode different proteins have been found for this gene. [provided by RefSeq, Jul 2008]
  • Mouse(140483) histamine N-methyltransferase
  • Rat(81676) histamine N-methyltransferase
  • chicken(424298) histamine N-methyltransferase
  • Zebrafish(445242) histamine N-methyltransferase
  • domestic cat(101093704) histamine N-methyltransferase
  • dog(476133) histamine N-methyltransferase
  • sheep(641310) histamine N-methyltransferase
  • cow(613413) histamine N-methyltransferase
  • domestic guinea pig(100135537) histamine N-methyltransferase
  • sheep(101102876) histamine N-methyltransferase

Custom & Knockdown Gene Products

  • siRNA

    Shop predesigned siRNA that are designed using the proprietary Rosetta Inpharmatics algorithm.

  • shRNA

    Shop the largest, most validated shRNA collection and build your own clone sets.

  • Custom Gene Products

    We offer a comprehensive portfolio of DNA oligos, RNA oligos and predesigned primers.

Antibodies

Product Number
Description
Species Reactivity
Application
HPA073754
Anti-HNMT antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human
Application
immunofluorescence
western blot