HMGCL
3-hydroxymethyl-3-methylglutaryl-CoA lyase
Synonyms:
HL
Species:
Human HMGCL (3155), Mouse Hmgcl (15356), Rat Hmgcl (79238), Zebrafish hmgcl (394190), naked mole-rat Hmgcl (101716848), domestic guinea pig Hmgcl (100713291), domestic cat HMGCL (101099569), cow HMGCL (317658), chicken HMGCL (396316), dog HMGCL (478187)
UniProtKB ID:
Gene ID:
- Human(3155) Summary: The protein encoded by this gene belongs to the HMG-CoA lyase family. It is a mitochondrial enzyme that catalyzes the final step of leucine degradation and plays a key role in ketone body formation. Mutations in this gene are associated with HMG-CoA lyase deficiency. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009]
- Mouse(15356) 3-hydroxy-3-methylglutaryl-Coenzyme A lyase
- Rat(79238) 3-hydroxymethyl-3-methylglutaryl-CoA lyase
- Zebrafish(394190) 3-hydroxymethyl-3-methylglutaryl-Coenzyme A lyase (hydroxymethylglutaricaciduria)
- naked mole-rat(101716848) 3-hydroxymethyl-3-methylglutaryl-CoA lyase
- domestic guinea pig(100713291) 3-hydroxymethyl-3-methylglutaryl-CoA lyase
- domestic cat(101099569) 3-hydroxymethyl-3-methylglutaryl-CoA lyase
- cow(317658) 3-hydroxymethyl-3-methylglutaryl-CoA lyase
- chicken(396316) 3-hydroxymethyl-3-methylglutaryl-CoA lyase
- dog(478187) 3-hydroxymethyl-3-methylglutaryl-CoA lyase
- sheep(101119699) 3-hydroxymethyl-3-methylglutaryl-CoA lyase
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