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Merck

HDAC8

histone deacetylase 8

Synonyms:
CDLS5, HD8, HDACL1, MRXS6, RPD3, WTS
Species:
Human HDAC8 (55869), Mouse Hdac8 (70315), Rat Hdac8 (363481), domestic guinea pig Hdac8 (100721893), chicken HDAC8 (422182), Zebrafish hdac8 (406740), domestic cat HDAC8 (101096383), dog HDAC8 (480957), sheep HDAC8 (101110121), cow HDAC8 (540666)
UniProtKB ID:
Q9BY41, A6ND12, A6ND61, A6NET3, A6NJR3, A8MQ62, B4DKN0, B4DV22
Gene ID:
  • Human(55869) Summary: Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class I of the histone deacetylase family. It catalyzes the deacetylation of lysine residues in the histone N-terminal tails and represses transcription in large multiprotein complexes with transcriptional co-repressors. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009]
  • Mouse(70315) histone deacetylase 8
  • Rat(363481) histone deacetylase 8
  • domestic guinea pig(100721893) histone deacetylase 8
  • chicken(422182) histone deacetylase 8
  • Zebrafish(406740) histone deacetylase 8
  • domestic cat(101096383) histone deacetylase 8
  • dog(480957) histone deacetylase 8
  • sheep(101110121) histone deacetylase 8
  • cow(540666) histone deacetylase 8
  • naked mole-rat(101697998) histone deacetylase 8

Custom & Knockdown Gene Products

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  • Custom Gene Products

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Antibodies

Product Number
Description
Species Reactivity
Application
H6412
Monoclonal Anti-Histone Deacetylase 8 (HDAC8) antibody produced in mouse, 2.0-2.5 mg/mL, clone HDAC8-48, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
ELISA
microarray
western blot
SAB4504424
Anti-phospho-HDAC8 (pSer39) antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human, mouse, rat
Application
ELISA
immunohistochemistry
western blot
07-505
Anti-HDAC8 Antibody, serum, Upstate®,
Species Reactivity
human, mouse
Application
immunoprecipitation (IP)
western blot
WH0055869M1
Monoclonal Anti-HDAC8 antibody produced in mouse, clone 2F4, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human, mouse, rat
Application
ELISA
immunofluorescence
western blot
SAB4502369
Anti-HDAC8 antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human, mouse, rat
Application
ELISA
immunohistochemistry
western blot

Small Molecule - Inhibitor

Product Number
Description
Species
T8552
Trichostatin A, ≥98% (HPLC), from Streptomyces sp.,
Species
human, mouse, rat
C0621
CI−994, ≥98% (HPLC), powder,
Species
human
SML1175
Romidepsin, ≥98% (HPLC),
Species
human

Kits

Product Number
Description
Species
EPI007
Histone Deacetylase 8 (HDAC8) Inhibitor Screening Kit, 100 assays in 96 well plates,
Species
human, mouse