GMDS
GDP-mannose 4,6-dehydratase
Synonyms:
GMD, SDR3E1
Species:
Human GMDS (2762), Mouse Gmds (218138), Rat Gmds (291095), domestic cat GMDS (101086651), dog GMDS (488189), Horse GMDS (100057325), Zebrafish gmds (393461), chicken GMDS (420890), sheep GMDS (101101931), cow GMDS (617688)
UniProtKB ID:
Gene ID:
- Human(2762) Summary: GDP-mannose 4,6-dehydratase (GMD; EC 4.2.1.47) catalyzes the conversion of GDP-mannose to GDP-4-keto-6-deoxymannose, the first step in the synthesis of GDP-fucose from GDP-mannose, using NADP+ as a cofactor. The second and third steps of the pathway are catalyzed by a single enzyme, GDP-keto-6-deoxymannose 3,5-epimerase, 4-reductase, designated FX in humans (MIM 137020).[supplied by OMIM, Aug 2009]
- Mouse(218138) GDP-mannose 4, 6-dehydratase
- Rat(291095) GDP-mannose 4, 6-dehydratase
- domestic cat(101086651) GDP-mannose 4,6-dehydratase
- dog(488189) GDP-mannose 4,6-dehydratase
- Horse(100057325) GDP-mannose 4,6-dehydratase
- Zebrafish(393461) GDP-mannose 4,6-dehydratase
- chicken(420890) GDP-mannose 4,6-dehydratase
- sheep(101101931) GDP-mannose 4,6-dehydratase
- cow(617688) GDP-mannose 4,6-dehydratase
- naked mole-rat(101703718) GDP-mannose 4,6-dehydratase
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