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F2

coagulation factor II (thrombin)

Synonyms:

PT, RPRGL2, THPH1

Species:

Human F2 (2147), Mouse F2 (14061), Rat F2 (29251), naked mole-rat F2 (101720561), domestic guinea pig F2 (100725988), sheep F2 (100307041), cow F2 (280685), domestic cat F2 (101090463), dog F2 (100686115), chicken F2 (395306)

UniProtKB ID:

P00734, B2R7F7, B4E1A7, Q4QZ40, Q53H04, Q53H06, Q7Z7P3, Q9UCA1

Gene ID:

Human(2147) Summary: Coagulation factor II is proteolytically cleaved to form thrombin in the first step of the coagulation cascade which ultimately results in the stemming of blood loss. F2 also plays a role in maintaining vascular integrity during development and postnatal life. Mutations in F2 leads to various forms of thrombosis and dysprothrombinemia. [provided by RefSeq, Jul 2008]
Mouse(14061) coagulation factor II
Rat(29251) coagulation factor II
naked mole-rat(101720561) coagulation factor II (thrombin)
domestic guinea pig(100725988) coagulation factor II (thrombin)
sheep(100307041) coagulation factor II (thrombin)
cow(280685) coagulation factor II (thrombin)
domestic cat(101090463) coagulation factor II (thrombin)
dog(100686115) coagulation factor II (thrombin)
chicken(395306) coagulation factor II (thrombin)
Zebrafish(325881) coagulation factor II (thrombin)

Products (19)
Peer Reviewed Papers (2,358)

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Antibodies

Product Number

Description

Species Reactivity

Application

Anti-Prothrombin Antibody, clone GMA-095, clone GMA-095, Upstate^®, from mouse,

Species Reactivity

human

Application

ELISA
western blot

Anti-Thrombin Antibody, clone GMA-020, clone GMA-020, Upstate^®, from mouse,

Species Reactivity

human

Application

western blot

Small Molecule - Inhibitor

Product Number

Description

Species

Sulfaguanidine, ,

Species

human

Benzamidine, ≥95.0%,

Species

human

(Aminomethyl)phosphonic acid, 99%,

Species

rat, human

α-Sexithiophene, ,

Species

human, rat

2,2′:5′,2′′:5′′,2′′′-Quaterthiophene, 96%,

Species

human, rat, mouse

Proteins

Product Number

Description

Species

Thrombin from human plasma, 400-1000 NIH units/mg protein,

Species

human

Thrombin from human plasma, lyophilized powder, ≥2800 NIH units/mg protein (E1%/280, 18.3),

Species

human

Thrombin from human plasma, lyophilized powder, 1500-3500 NIH units/mg protein (E1%/280, 18.3), suitable for cell culture,

Species

human

Thrombin from human plasma, lyophilized powder, ≥1,000 NIH units/mg protein (E1%/280, 18.3),

Species

human

Thrombin from human plasma, lyophilized powder, ≥2,000 NIH units/mg protein (E1%/280, 18.3),

Species

human