DUOX1
dual oxidase 1
Synonyms:
LNOX1, NOXEF1, THOX1
Species:
Human DUOX1 (53905), Mouse Duox1 (99439), Rat Duox1 (266807), sheep DUOX1 (101111972), domestic guinea pig Duox1 (100713662), naked mole-rat Duox1 (101698133), Domestic Rabbit DUOX1 (100344845), cow DUOX1 (510409), dog DUOX1 (403720), domestic cat DUOX1 (101091374)
UniProtKB ID:
Gene ID:
- Human(53905) Summary: The protein encoded by this gene is a glycoprotein and a member of the NADPH oxidase family. The synthesis of thyroid hormone is catalyzed by a protein complex located at the apical membrane of thyroid follicular cells. This complex contains an iodide transporter, thyroperoxidase, and a peroxide generating system that includes proteins encoded by this gene and the similar DUOX2 gene. This protein is known as dual oxidase because it has both a peroxidase homology domain and a gp91phox domain. This protein generates hydrogen peroxide and thereby plays a role in the activity of thyroid peroxidase, lactoperoxidase, and in lactoperoxidase-mediated antimicrobial defense at mucosal surfaces. Two alternatively spliced transcript variants encoding the same protein have been described for this gene. [provided by RefSeq, Jul 2012]
- Mouse(99439) dual oxidase 1
- Rat(266807) dual oxidase 1
- sheep(101111972) dual oxidase 1
- domestic guinea pig(100713662) dual oxidase 1
- naked mole-rat(101698133) dual oxidase 1
- Domestic Rabbit(100344845) dual oxidase 1
- cow(510409) dual oxidase 1
- dog(403720) dual oxidase 1
- domestic cat(101091374) dual oxidase 1
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