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Merck

CYP17A1

cytochrome P450, family 17, subfamily A, polypeptide 1

Synonyms:
CPT7, CYP17, P450C17, S17AH
Species:
UniProtKB ID:
Gene ID:
  • Human(1586) Summary: This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum. It has both 17alpha-hydroxylase and 17,20-lyase activities and is a key enzyme in the steroidogenic pathway that produces progestins, mineralocorticoids, glucocorticoids, androgens, and estrogens. Mutations in this gene are associated with isolated steroid-17 alpha-hydroxylase deficiency, 17-alpha-hydroxylase/17,20-lyase deficiency, pseudohermaphroditism, and adrenal hyperplasia. [provided by RefSeq, Jul 2008]
  • Mouse(13074) cytochrome P450, family 17, subfamily a, polypeptide 1
  • Rat(25146) cytochrome P450, family 17, subfamily a, polypeptide 1
  • Horse(100034232) cytochrome P-450 17 alpha-hydroxylase/C17,20-lyase
  • Zebrafish(399692) cytochrome P450, family 17, subfamily A, polypeptide 1
  • cow(281739) cytochrome P450, family 17, subfamily A, polypeptide 1
  • sheep(493968) cytochrome P450, family 17, subfamily A, polypeptide 1
  • domestic cat(493967) cytochrome P450, family 17, subfamily A, polypeptide 1
  • chicken(425056) cytochrome P450, family 17, subfamily A, polypeptide 1
  • dog(477807) cytochrome P450, family 17, subfamily A, polypeptide 1

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Small Molecule - Inhibitor

Product Number
Description
Species
Abiraterone acetate, United States Pharmacopeia (USP) Reference Standard,
Species
human
Abiraterone acetate, ≥98% (HPLC),
Species
human
Galeterone, ≥98% (HPLC),
Species
human
(R)-(+)-Aminoglutethimide, 97%,
Species
human
(S)-(−)-Aminoglutethimide, 97%,
Species
human