CHEK2
checkpoint kinase 2
Synonyms:
CDS1, CHK2, HuCds1, LFS2, PP1425, RAD53, hCds1
Species:
Human CHEK2 (11200), Mouse Chek2 (50883), Rat Chek2 (114212), domestic guinea pig Chek2 (100727440), sheep CHEK2 (101105532), cow CHEK2 (518897), domestic cat CHEK2 (101085665), Horse CHEK2 (100059288), dog CHEK2 (486338), chicken CHEK2 (768913) ...More
UniProtKB ID:
Gene ID:
- Human(11200) Summary: In response to DNA damage and replication blocks, cell cycle progression is halted through the control of critical cell cycle regulators. The protein encoded by this gene is a cell cycle checkpoint regulator and putative tumor suppressor. It contains a forkhead-associated protein interaction domain essential for activation in response to DNA damage and is rapidly phosphorylated in response to replication blocks and DNA damage. When activated, the encoded protein is known to inhibit CDC25C phosphatase, preventing entry into mitosis, and has been shown to stabilize the tumor suppressor protein p53, leading to cell cycle arrest in G1. In addition, this protein interacts with and phosphorylates BRCA1, allowing BRCA1 to restore survival after DNA damage. Mutations in this gene have been linked with Li-Fraumeni syndrome, a highly penetrant familial cancer phenotype usually associated with inherited mutations in TP53. Also, mutations in this gene are thought to confer a predisposition to sarcomas, breast cancer, and brain tumors. This nuclear protein is a member of the CDS1 subfamily of serine/threonine protein kinases. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012]
- Mouse(50883) checkpoint kinase 2
- Rat(114212) checkpoint kinase 2
- domestic guinea pig(100727440) checkpoint kinase 2
- sheep(101105532) checkpoint kinase 2
- cow(518897) CHK2 checkpoint homolog (S. pombe)
- domestic cat(101085665) checkpoint kinase 2
- Horse(100059288) checkpoint kinase 2
- dog(486338) checkpoint kinase 2
- chicken(768913) checkpoint kinase 2
- Zebrafish(336998) CHK2 checkpoint homolog (S. pombe)
- naked mole-rat(101721212) checkpoint kinase 2
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Antibodies
Product Number
Description
Species Reactivity
Application
Anti-phospho-Chk2 (pThr68) antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human, mouse, rat
Application
ELISA
immunohistochemistry
western blot
immunohistochemistry
western blot
Monoclonal Anti-Chk2 antibody produced in mouse, clone DCS-270, purified from hybridoma cell culture,
Species Reactivity
human
Application
immunocytochemistry
immunohistochemistry
immunoprecipitation (IP)
microarray
western blot
immunohistochemistry
immunoprecipitation (IP)
microarray
western blot
Anti-Phospho-CHEK2-S19 antibody produced in rabbit, ,
Species Reactivity
human
Application
western blot
Anti-Phospho-CHEK2-S516 antibody produced in rabbit, ,
Species Reactivity
human, mouse, rat
Application
western blot
Anti-Phospho-CHEK2-S33/35 antibody produced in rabbit, ,
Species Reactivity
human
Application
western blot
Small Molecule - Inhibitor
Product Number
Description
Species
Proteins
Product Number
Description
Species
CHK2 Protein, active, 10 µg, Active, recombinant human CHK2, residues 5-543, containing N-terminal GST & C-terminal His-6 tags, for use in Kinase Assays.,
Species
human